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1.
J Postgrad Med ; 1983 Oct; 29(4): 218-22
Artigo em Inglês | IMSEAR | ID: sea-116364
3.
Indian J Physiol Pharmacol ; 1982 Jul-Sep; 26(3): 227-30
Artigo em Inglês | IMSEAR | ID: sea-107056

RESUMO

Mn++ produced hypoglycemia in normal rats. The effect was dose-dependent. However, Mn++ did not produce hypoglycemia in alloxan-treated rats. There was a rise in liver glycogen following Mn++ treatment which was correlated with fall in blood sugar at 1 1/2 and 3 hr. There was also increase in the glucose uptake by rat diaphragm upto 47% between 2 and 3 hr. The results suggest that functioning, intact pancreatic beta-cells are necessary for the action of Mn++ and that Mn++ may have a peripheral effect on glucose entry into the cells.


Assuntos
Animais , Glicemia/análise , Diabetes Mellitus Experimental/sangue , Diafragma/metabolismo , Feminino , Glucose/metabolismo , Hipoglicemia/induzido quimicamente , Glicogênio Hepático/metabolismo , Masculino , Manganês/farmacologia , Ratos
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