RESUMO
Objectives: Transforming growth factor-betas [TGF[beta]s] are multifunctional growth factors with a broad range of biological activities in various cell types in many different tissues. The purpose of this study was to evaluate the treatment of intrabony defects with anorganic bovine bone mineral matrix combined with TGF[beta]-1 with the use of anorganic bovine bone alone
Materials and Methods: Thirty-two sites from sixteen patients were selected using a split-mouth study design for each patient, determined randomly through a biased coin randomization. One site received a mucoperiosteal flap, and the osseous defect was fi lled with the combined therapy [Group 1]. The other site treated was with anorganic bovine bone alone and served as a control [Group 2]. All the treated sites were covered with a bioabsorbable collagen membrane. The clinical parameters and radiographic follow-up examinations were recorded after 3, 6, 9, and 12 months
Results: Clinically, there was a statistically signifi cant gain in the clinical attachment level [+5.03 +/- 0.14 mm] and a statistically signifi cant reduction of pocket probing depth [?5.16 mm +/- 0.13] for Group 1 sites compared to sites in Group 2 [P
Conclusions: The use of anorganic bovine bone mineral matrix combined with TGF[beta]-1 seemed to be effective in the treatment of intrabony defects. This showed an improvement in the clinical outcome of periodontal therapy superior to the use of anorganic bovine bone on its own