Evaluation for disease-specific quality of life in children with sleep-disordered breathing / 中华全科医师杂志

Objective To evaluate the impact of sleep-disordered breathing(SDB)on the quality of life(QOL)in children with SDB and investigate the value of tonsillectomy and adenoidectomy in improving their QOL.Methods Questionnaire of disease-specific quality of life for children with obstructive sleep apnea with 18 items(OSA-18)was used to evaluate QOL in 168 children with SDB within four weeks before and six to 12 months after surgical operation,and correlation between OSA-18 scores to apnea hypopnea index(AHI)and minimum oxygen saturation(MiO2)in 62 of them was evaluated with polysomnography(PSG),with 50 healthy children without snoring as controls.Results Overall scores of OSA-18 in children of SDB group before surgical operation were significantly higher than those in children of control group(t=15.12,P＜0.01).and QOL was seriously affected in 30.4 percent of the children with SDB.Scores of OSA-18 correlated to AHI and MiO2 before surgical operation.QOL was improved significantly in 73.8 percent of children with SDB after tonsillectomy and adenoidectomy.Conclusions SDB has obvious impact on pediatric QOL,which can be improved by tonsillectomy and adenoidectomy.There exists significant correlation between OSA-18 scores and objective indicators of PSG,and the former can be used as clinical diagnosis for SDB in children and as quantitative evaluation for the effectiveness of intervention.

The Relationship Between the Expression ofMetalloproteinase- 2 and Laryngeal Squamous Cell Carcinoma / 上海第二医科大学学报

Objective To study the relationship between the expression of matrix metallopro-teinase- 2(MMP- 2) and the clinical pathological characteristics of laryngeal squamous cell carcinoma.Methods Irnmunohistochemistry technique (ABC) was used to detect the expression and location ofMMP- 2 in the tissue of 43 cases with laryngeal squamous cell carcinoma. ResultsThe positive ex-pression rate of the MMP - 2 protein was 29(67.4% ) among the 43 laryngeal tumor tissues. It was sig-nificantly related to metastasis of the cervical lymph nodes (P<0.05). MMP- 2 was immunolocalizedon the membranes and intracytoplasm of metastatic cluster tumor cells or the tumor cells adjacent to thebasement membrane. ConclusionThese results suggest that MMP- 2 plays an important role in thetumor invasion and metastasis of laryngeal squamous cell carcinoma.