RESUMO
Ginseng (Panax ginseng) and Ashwagandha (Withania somnifera) are widely used as geriatric tonics. Both individually have not shown any toxicity on long term administration. Study was planned to assess the safety of the combination by doing subacute toxicity study in rats with 90 days oral administration using three doses. Food consumption, body weight, haematological, biochemical and histopathological parameters were studied. There was significant increase in body weight, food consumption and liver weight, and improved hematopoiesis was observed. Brain, heart, lung, liver, spleen, kidneys, stomach, testis and ovaries were normal on gross examination and histopathologically. Subacute toxicity studies in rats did not reveal any toxicity.
Assuntos
Administração Oral , Animais , Anti-Inflamatórios não Esteroides/toxicidade , Combinação de Medicamentos , Ingestão de Alimentos/efeitos dos fármacos , Feminino , Hemoglobinas/metabolismo , Fígado/efeitos dos fármacos , Masculino , Tamanho do Órgão/efeitos dos fármacos , Panax , Extratos Vegetais/toxicidade , Plantas Medicinais , Ratos , Aumento de Peso/efeitos dos fármacos , WithaniaRESUMO
Congenital plexiform neurofibroma is regarded as pathognomonic of neurofibromatosis (NF) especially when it is large and involves a major nerve trunk with changes of elephantiasis neuromatosa. Only very rarely malignant changes have been reported in cases who have NF for less than 5 years. 'Borderline' lesions are seen especially in patients with NF. In such cases criteria of mitotic activity should be utilized in establishing the diagnosis of malignancy. A case of 3 month child with congenital plexiform neurofibroma involving neck with elephantiasis neuromatosa with sarcomatous nodule has been described in the present article. The criteria for malignancy in nerve sheath tumors have also been discussed.
Assuntos
Dorso , Humanos , Lactente , Masculino , Pescoço , Neoplasias Primárias Múltiplas/congênito , Neurofibroma Plexiforme/congênito , Neurofibrossarcoma/congênito , Neoplasias de Tecidos Moles/congênitoRESUMO
A male child aged six years presented with a swelling in neck and hypertension. He was diagnosed to have and operated for Carotid body paraganglioma with Coexistent pheochromocytoma. Hypertension persisted even after excision of both the tumours which could be controlled with anti-hypertensive agents. The case is discussed with review of literature.