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1.
Journal of the Korean Ophthalmological Society ; : 1435-1440, 2016.
Artigo em Coreano | WPRIM | ID: wpr-32966

RESUMO

PURPOSE: To evaluate the clinical characteristics and prognoses of children with functional visual loss. METHODS: Retrospective medical record review was performed in 53 patients 4 to 16 years of age diagnosed with functional visual loss between April 2006 and February 2014. We investigated the clinical features and results of clinical tests and the final status of the patients. RESULTS: Twenty male (37.8%) and 33 female (62.2%) patients were included in the study. The mean age was 9.69 ± 2.76 years. The incidence was highest between 8 to 12 years. The mean best corrected visual acuity at baseline was 0.43 ± 0.23, and 88.7% of patients had mild to moderate visual loss. The symptoms were bilateral in 96.2% of patients, and the difference of corrected visual acuity between two eyes was 1 line or less on Snellen chart in 94.1% of bilateral cases. The symptoms were resolved by 1.8 ± 1.0 months in 59.5% of patients and resolved by the final follow-up visit in 51 (96.2%). However, the symptoms persisted through the final follow-up in 2 patients. CONCLUSIONS: Most children with functional visual loss have bilateral and mild to moderate visual loss. The prognosis of functional visual loss in children was excellent. Most patients recovered from the disease with reassurance supportive care without psychiatric treatment, although a few patients had persistent symptoms.


Assuntos
Criança , Feminino , Humanos , Masculino , Seguimentos , Incidência , Prontuários Médicos , Prognóstico , Estudos Retrospectivos , Acuidade Visual
2.
Yonsei Medical Journal ; : 1326-1332, 2014.
Artigo em Inglês | WPRIM | ID: wpr-210326

RESUMO

PURPOSE: To find out the possible role of 1,25(OH)2 vitamin D3 [1,25(OH)2D3] and parathyroid hormone (PTH) as intrinsic factors in urinary calcium stone formers (SFs), we investigated their relationship with serum and urinary biochemical parameters. MATERIALS AND METHODS: A total of 326 calcium SFs (male: 204, female: 122) were enrolled and underwent outpatient metabolic evaluations including 1,25(OH)2D3 and PTH as well as serum and 24-hour urinary biochemical parameters. As control, 163 age- and sex-matched (2:1) individuals (non-SFs) who have never urinary stone episode were included. RESULTS: 1,25(OH)2D3 level was positively correlated with urinary calcium excretion (r=0.347, p<0.001). The hypercalciuric group and recurrent SFs had higher serum 1,25(OH)2D3 levels than the normocalciuric group (p<0.001) and first SFs (p=0.050). In the adjusted multiple linear regression analysis, serum 1,25(OH)2D3 level (beta=0.259, p<0.001) and serum PTH level (beta=-0.160, p<0.001) were significantly correlated with urinary calcium excretion. The patients in highest tertile of 1,25(OH)2D3 had a more than 3.1 fold risk of hypercalciuria than those in the lowest tertile (odds ratio=3.14, 95% confidence interval: 1.431-6.888, p=0.004). No correlation was observed between PTH and 1,25(OH)2D3 (R=0.005, p=0.929) in calcium SFs, while a negative correlation was found in controls (R=-0.269, p=0.001). CONCLUSION: 1,25(OH)2D3 was closely correlated with urinary calcium excretion, and high 1,25(OH)2D3 levels were detected in the hypercalciuric group and in recurrent SFs. However, 1,25(OH)2D3 was not correlated with PTH in calcium SFs. These findings suggest that 1,25(OH)2D3 might be important intrinsic factor for altered calcium regulation in SFs.


Assuntos
Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Cálcio/metabolismo , Cálculos Renais , Modelos Lineares , Análise Multivariada , Razão de Chances , Hormônio Paratireóideo/sangue , Vitamina D/análogos & derivados
3.
Korean Journal of Medicine ; : 444-452, 2014.
Artigo em Coreano | WPRIM | ID: wpr-192839

RESUMO

BACKGROUND/AIMS: Urinary tract obstruction induces a form of renal tubular acidosis with a urinary acidification defect caused by decreasing net acid excretion, which is predominantly due to a decrease in urinary ammonia excretion. The present study examined whether this decrease is associated with changes in the renal expression of an ammonia transporter family member, Rh C glycoprotein (Rhcg), in rats with a unilateral ureteral obstruction. METHODS: Male Sprague-Dawley rats underwent a 24-h unilateral ureteral obstruction. Rhcg expression was then evaluated by immunoblotting and immunohistochemistry. Cell height, total cellular expression, expression in the apical 25% of the cell, and % of total expression in the apical region were quantified by immunohistochemistry with quantitative morphometric analysis. RESULTS: After 24 h of unilateral ureteral obstruction, the serum bicarbonate level and total urinary ammonia excretion were decreased. Both light microscopy and immunohistochemistry with quantitative morphometric analysis demonstrated that the total intensity of Rhcg expression was decreased in the obstructed kidneys, whereas Rhcg expression did not change in the cortical collecting duct (CCD) and outer medullary collecting duct (OMCD) of nonobstructed kidneys in rats with a 24-h unilateral ureteral obstruction. CONCLUSIONS: The rats with a unilateral ureteral obstruction showed decreased urinary ammonia excretion associated with decreased Rhcg expression in the CCD and OMCD. These changes suggest that the ammonia transporter Rhcg mediates a urinary acidification defect associated with unilateral ureteral obstruction.


Assuntos
Animais , Humanos , Masculino , Ratos , Acidose , Acidose Tubular Renal , Amônia , Glicoproteínas , Immunoblotting , Imuno-Histoquímica , Rim , Túbulos Renais , Microscopia , Ratos Sprague-Dawley , Ureter , Obstrução Ureteral , Sistema Urinário
4.
Journal of Korean Medical Science ; : 1079-1084, 2012.
Artigo em Inglês | WPRIM | ID: wpr-154180

RESUMO

The study was designed to investigate the effect of serum glucose, insulin and insulin resistance on the risk of prostate cancer (CaP) and on the clinicopathological characteristics in Korean men. Subjects were retrospectively recruited from 166 CaP patients underwent radical prostatectomy and 166 age-matched benign prostatic hyperplasia (BPH) patients. The serum was taken on the morning of the day of operation and insulin resistance was assessed by homeostasis model assessment insulin resistance index (HOMA-IR). Men in highest tertile of insulin was associated with 55% reduced odds of CaP than those with the lowest tertile (OR = 0.45, 95% CI = 0.23-0.89, P = 0.022). The patients in highest tertile of insulin had a more than 5.6 fold risk of locally advanced stage than those in the lowest tertile (OR = 5.62, 95% CI = 1.88-16.83, P = 0.002). Moreover, the patients in the highest tertile HOMA-IR group was associated with an increased risk of locally advanced stage than the lowest tertile group (OR = 3.10, 95% CI = 1.07-8.99, P = 0.037). These results suggest that elevated insulin and insulin resistance are associated with the advanced pathological stage of prostate cancer in Korean patients.


Assuntos
Idoso , Humanos , Masculino , Pessoa de Meia-Idade , Povo Asiático , Glicemia/análise , Insulina/sangue , Resistência à Insulina , Gradação de Tumores , Razão de Chances , Antígeno Prostático Específico/sangue , Prostatectomia , Neoplasias da Próstata/etiologia , República da Coreia , Estudos Retrospectivos , Fatores de Risco
5.
Korean Circulation Journal ; : 38-42, 2011.
Artigo em Inglês | WPRIM | ID: wpr-224104

RESUMO

Sparganosis is caused by a larval tapeworm of the genus Spirometra, which commonly invades subcutaneous tissue, but less frequently invades muscle, intestines, spinal cord, and the peritoneopleural cavity. The authors managed a female patient who presented with a recurrent pericardiopleural effusion and peripheral eosinophilia. The anti-sparganum-specific IgG serum level was significantly higher than normal control levels. In this patient, sparganosis was caused by the ingestion of raw frogs in an effort to control her thyroid disease. The recurrent pericardiopleural effusion and peripheral eosinophilia were controlled by 3 consecutive doses of praziquantel (75 mg/kg/day). The patient is doing well 4 years after presentation. Sparganosis should be considered a rare, but possible cause of recurrent pericardial effusion and peripheral eosinophilia. Immunoserologic testing using enzyme linked immunosorbent assays can be helpful in diagnosing human sparganosis, especially in cases without a subcutaneous lump or mass. Praziquantel is an alternative treatment for sparganosis in surgically-unresectable cases.


Assuntos
Feminino , Humanos , Cestoides , Ingestão de Alimentos , Eosinofilia , Imunoglobulina G , Intestinos , Músculos , Derrame Pericárdico , Praziquantel , Esparganose , Medula Espinal , Spirometra , Tela Subcutânea , Doenças da Glândula Tireoide
6.
Korean Journal of Medicine ; : 687-696, 2011.
Artigo em Coreano | WPRIM | ID: wpr-201145

RESUMO

BACKGROUND/AIMS: Renal tubular acidosis (RTA) decreases the net acid excretion, predominantly due to a decrease in urinary ammonia excretion. This study examined whether this decrement is associated with changes in the renal expression of the ammonia transporter family members, Rh B glycoprotein (Rhbg) and Rh C glycoprotein (Rhcg), in rats with amiloride-induced RTA. METHODS: Male Sprague-Dawley rats were treated intraperitoneally with amiloride (3 mg/kg/day) for 6 days. Rhbg and Rhcg expression was evaluated by immunoblotting and immunohistochemistry. Cell height, total cellular expression, expression in the apical 25% of the cell, and apical expression as a percentage of total expression were quantified using immunohistochemistry with quantitative morphometric analysis. RESULTS: After amiloride treatment for 6 days, the serum bicarbonate level was decreased, and serum potassium was increased. The total urinary ammonia excretion and potassium excretion were decreased. The total Rhbg and Rhcg protein expression levels were not changed in the cortex or outer medulla of the kidney. Light microscopy and immunohistochemistry with quantitative morphometric analysis demonstrated that total Rhcg expression was decreased in the cortical collecting duct (CCD) and outer medullary collecting duct (OMCD) in amiloride-induced RTA, whereas Rhbg immunoreactivity was unchanged. CONCLUSIONS: Rats with amiloride-induced RTA have decreased urinary ammonia excretion associated with decreased Rhcg expression in the CCD and OMCD, suggesting that the ammonia transporter Rhcg plays an important role in the pathogenesis of amiloride-induced RTA.


Assuntos
Animais , Humanos , Masculino , Ratos , Acidose Tubular Renal , Amilorida , Amônia , Glicoproteínas , Immunoblotting , Imuno-Histoquímica , Rim , Túbulos Renais Coletores , Luz , Microscopia , Potássio , Ratos Sprague-Dawley
7.
Journal of the Korean Society of Magnetic Resonance in Medicine ; : 158-165, 2002.
Artigo em Coreano | WPRIM | ID: wpr-175541

RESUMO

PURPOSE: To evaluate the effect of Gd-DTPA on signal intensity of diffusion-weighted magnetic resonance (MR) image and apparent diffuse coefficient (ADC) in dog brain with hyperacute stroke. MATERIALS AND METHODS: Experimental canine model of hyperacute cerebral infarction was made by selective intraarterial embolization with particulate embolic material. Diffusion-weighted MR imaging was performed in five dogs at 1 hour after the embolization of internal carotid artery. After intravenous bolus injection of Gd-DTPA, additional 11 diffusion-weighted MR images were serially obtained from 2 minutes to 90 minutes after injection in each dog. The author evaluated findings of hyperacute cerebral infarction on diffusion-weighted MR imaging, and calculated mean signal intensity and mean ADC in infarcted region and contralateral normal region. Statistical analysis of mean signal intensity, mean ADC and contrast-noise ratio before and after Gd-DTPA injection was performed. RESULTS: Hyperacute cerebral infarction developed in all five dogs on diffusion-weighted MR images obtained 1 hour after embolization. The area of hyperacute infarction had steady increase in signal intensity on diffusion-weighted MR image and decrease in ADC. In normal perfusion area, decrease in signal intensity was observed at 2 minutes the Gd-DTPA injection, whereas ADC did not changed. CONCLUSION: Intravenous injection of Gd-DTPA had no influence on ADC in both hyperacute infarction and normally perfused area, but caused initial transient signal reduction in normally perfused area on diffusion-weighted MR image due to susceptibility effect of Gd-DTPA. It is important to calculate ADC in evaluating the effect of diffusion after injection of Gd-DTPA.


Assuntos
Animais , Cães , Encéfalo , Artéria Carótida Interna , Infarto Cerebral , Difusão , Gadolínio DTPA , Infarto , Injeções Intravenosas , Imageamento por Ressonância Magnética , Perfusão , Acidente Vascular Cerebral
8.
Korean Journal of Nuclear Medicine ; : 89-99, 2001.
Artigo em Coreano | WPRIM | ID: wpr-92810

RESUMO

PURPOSE: In this study, we developed a new software tool for the analysis of renal scintigraphy which can be modified more easily by a user who needs to study new clinical applications, and the appropriateness of the results from our program was studied. MATERIALS AND METHODS: The analysis tool was programmed with IDL5.2 and designed for use on a personal computer running Windows. For testing the developed tool and studying the appropriateness of the calculated glomerular filtration rate (GFR), 99mTc-DTPA was administered to 10 adults in normal condition. In order to study the appropriateness of the calculated mean transit time (MTT), 99mTc-DTPA and 99mTc-MAG3 were administered to 11 adults in normal condition and 22 kidneys were analyzed. All the images were acquired with ORBITOR, the Siemens gamma camera. RESULTS: With the developed tool, we could show dynamic renal images and time activity curve (TAC) in each ROI and calculate clinical parameters of renal function. The results calculated by the developed tool were not different statistically from the results obtained by the Siemens application program (Tmax: p=0.68, Relative Renal Function: p=1.0, GFR: p=0.25) and the developed program proved reasonable. The MTT calculation tool proved to be reasonable by the evaluation of the influence of hydration status on MTT. CONCLUSION: We have obtained reasonable clinical parameters for the evaluation of renal function with the software tool developed in this study. The developed tool could prove more practical than conventional, commercial programs.


Assuntos
Adulto , Humanos , Câmaras gama , Taxa de Filtração Glomerular , Rim , Microcomputadores , Medicina Nuclear , Cintilografia , Corrida , Tecnécio Tc 99m Mertiatida
9.
Journal of the Korean Radiological Society ; : 793-799, 1998.
Artigo em Coreano | WPRIM | ID: wpr-216117

RESUMO

PURPOSE: To evaluate the frequency of peritumoral bone marrow(BM) edema accompanying benign giant celltumor(GCT) of the appendicular bone by magnetic resonance(MR) imaging and to correlate MRI findings with those ofplain radiography and bone scintigraphy. MATERIALS AND METHODS: Eighteen cases of pathologically proven benignGCT of the appendicular bone were retrospectively analyzed using MR images, plain radiographs and bonescintigrams. A plain radiograph was available in 15 cases, and a scintigram in six. Marrow edema was defined asperitumoral signal changes which were of homogeneous intermediate or low signal intensity(SI) on T1WI and high SIon T2WI, relative to the SI of normal BM, and homogeneous enhancement on Gd-DTPA-enhanced T1WI. The transitionzone, sclerotic margin and aggressiveness of the lesion were assessed on the basis of plain radiographs. BM edemaseen on MR images was correlated with plain radiographic and scintigraphic findings. RESULTS: 1. Peritumoral BMedema was seen on MR images in 10 of 18 cases (55.5%). 2. In 8 of 15 cases for which plain radiographs wereavailable, MR imaging revealed BM edema. In six of these eight, transition zone was wide, while in two it wasnarrow. Six of seven patients without marrow edema showed a wide transition zone, and in one this was narrow.There was significant correlation between BM edema shown by MR imaging and the transition zone seen on plainradiographs (x2, p<0.05). But The aggressiveness shown by plain radiographs correlated only marginally, while thepresence of sclerotic rim did not correlate. 3. All six cases for which a bone scintigram was available showed anextended uptake pattern. In five of the six, MR imaging revealed edema. CONCLUSION: Peritumoral BM edema wasfrequently seen (55.5%) in the GCTs of appendicular bone ; it was more often shown in association with a widetransition zone by plain radiographs.


Assuntos
Humanos , Medula Óssea , Edema , Tumores de Células Gigantes , Células Gigantes , Imageamento por Ressonância Magnética , Radiografia , Cintilografia , Estudos Retrospectivos
10.
Journal of the Korean Society for Therapeutic Radiology ; : 249-258, 1993.
Artigo em Inglês | WPRIM | ID: wpr-169666

RESUMO

Between March 1983 and December 1989, ninety-six patients with intracranial glioma were treated in the Department of Therapeutic Radiology, Kangnam St. Mary's Hospital, Catholic University Medical College. We retrospectively reviewed each case to evaluate variable factors influencing the treatment results and to develop an optimal therapy Policy. Median follow-up is 57 months(range:31~133 months). Of the 96 patients, 60(63%) were males and 36(37%) were females. Ages ranged from 3 to 69 years (median 42 years). The most common presenting symtoms were headache(67%) followed by cerebral motor and sensory discrepancy(54%), nausea and vomiting(34%), seizure (19%), mental change(10%) and memory and calculation impairment(8%). Eighty five(88.5%) patients all, except 11(11.5%) brain stem lesions, were biopsy proven intracranial glioma. The distribution by histologic type was 64 astrocytomas(75%), 4 mixed oligoastrocytomas(5%), and 17 oligodendrogliomas(20%). Fourty nine patients (58%) were grade I,II histology and 36 (42%) patients were grade III, IV histology. Of the 96 patients, 64(67%) recieved postoperative RT and 32(33%) were treated with primary radiotherapy. Gross total resection was performed in 14(16%) patients, subtotal resection in 29(34%), partial resection in 21(25%), and biopsy only in 21(25%). Median survival time was 53 months(range 2~133 months), and 2- and, 5-year survival rate were 69%, 49% respectively. 5-year survival rate by histologic grade was gradeI, 70%, gradeII, 58%, grade III, 28%, and grade IV, 15%. Multivariated analysis demonstrate that age at diagnosis (p=0.121), Karnofsky performance Status(KPS)(p=0.0002), histologic grade(p=0.0001), postoperative radiation therapy(p=0.0278), surgical extent(p=0.024), cerebellar location of tumor(p=0.0095) were significant prognostic factors influencing on survival.


Assuntos
Feminino , Humanos , Masculino , Biópsia , Tronco Encefálico , Diagnóstico , Seguimentos , Glioma , Memória , Náusea , Radioterapia (Especialidade) , Radioterapia , Estudos Retrospectivos , Convulsões , Taxa de Sobrevida
11.
Korean Journal of Urology ; : 39-44, 1988.
Artigo em Coreano | WPRIM | ID: wpr-23293

RESUMO

Extracorporeal shock wave lithotripsy has proved to be an effective method of treating urinary calculi. A total of 110 patients underwent 244 treatments with extracorporeal shock wave lithotripsy for urinary calculi from May 1987 to July 1987. Analysis of the first 110 patients shows 80 renal and 30 ureteral stones. The overall(complete and incomplete) success rate was 93.6%, and low morbidity and no mortality were proved. Extracorporeal shock wave lithotripsy is the preferred form of management for renal and ureteral stone less than 2cm in diameter.


Assuntos
Humanos , Litotripsia , Mortalidade , Choque , Ureter , Cálculos Urinários
12.
Journal of the Korean Pediatric Society ; : 95-99, 1986.
Artigo em Coreano | WPRIM | ID: wpr-208377

RESUMO

No abstract available.


Assuntos
Fístula Arteriovenosa , Cianose
13.
Journal of Korean Neurosurgical Society ; : 25-44, 1976.
Artigo em Coreano | WPRIM | ID: wpr-64194

RESUMO

The authors analysed radiologic findings of the posterior fossa lesions as well as incisural and supratentorial lesions in 40 patients who were diagnosed by transfemoral serial vertebral angiography at Catholic Medical Center since October 1972 to April 1976. We also attempted to evaluate the diagnostic value in the diagnosis of the lesions according to the site of involvement. The tumors of the fourth ventricle or vermis demonstrated abnormal findings corresponding to the area of involvement, however the lesion could not be defined accurately with the study. Cerebellar hemispheric or tentorial tumors were diagnosed with considerable accuracy by vertebral angiography. Infratentorial vascular lesions were clearly demonstrated with serial vertebral angiography but the accuracy of diagnosis was argumented with subtraction technique. The evidence of compression of the brain stem was demonstrated with considerable accuracy by serial vertebral angiography. Furthermore exact site and direction of the compression could be outlined with the study. For the posterior temporal or occipital tumors which were not able to diagnose definitely with carotid angiography, considerable diagnostic accuracy was carried by the vertebral angiography. Definite diagnosis of the posterior third ventricle tumors or thalamic lesions was able to obtain with serial vertebral angiography.


Assuntos
Humanos , Angiografia , Tronco Encefálico , Encéfalo , Diagnóstico , Quarto Ventrículo , Técnica de Subtração , Terceiro Ventrículo
14.
Journal of the Korean Ophthalmological Society ; : 11-13, 1969.
Artigo em Coreano | WPRIM | ID: wpr-182446

RESUMO

Authors observed clinically for congenital anophthalmos in two cases. One case was a boy, aged 6 years, having congenital anophthalmos of right eye with bifid uvula and another case was newbron baby, aged 4 days, having congenital anophthalmos and blepharophimosis of left eye and was born to undernutciented mother from chronic hepatitis.


Assuntos
Humanos , Masculino , Anoftalmia , Blefarofimose , Hepatite Crônica , Mães , Úvula
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