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Objective To investigate the change and clinical application value of plasma D‐dimer in acute cerebral hemorrhage . Methods The plasma D‐dimer level was detected in 78 individuals of healthy physical examination(healthy control group) and 82 patients with acute cerebral hemorrhage .Results The plasma D‐dimer levels at admission(0 h) had no statistical difference among various groups(P> 0 .05) ;the D‐dimer level at 24 ,48 ,72 h in the small cerebral hemorrhage group was significantly higher than that in the healthy control group(P< 0 .05) ;the D‐dimer level in the massive cerebral hemorrhage group was significantly higher than that in the small cerebral hemorrhage group(P< 0 .05) ;the D‐dimer level in the small cerebral hemorrhage group reached the peak at 24 h ,while which in the massive cerebral hemorrhage group reached the peak at 48 h and was positively correlated with the intracranial hemorrhage volume(r= 0 .914 ,P= 0 .000 < 0 .05) .Conclusion The plasma D‐dimer level in the patients with acute cer‐ebral hemorrhage is obviously increased and shows the increasing trend with the intracranial hemorrhage volume increase ;the more the intracranial hemorrhage volume ,the longer the persistence time of high D‐dimer level .Therefore detecting plasma D‐dimer level has an important significance for monitoring the condition in the patients with acute cerebral hemorrhage .
RESUMO
Objective: To investigate effects of different frash gas flow of oxygen ventila-tion on emergence time and delirium undergoing Enflurane general anesthesia. Methods: Forty- eight patients, ASA Ⅰ- Ⅱ, aged 33- 68yr, mean 50.5yr, underwent elective abdominal op-eration were randomly divided into three groups according to the different frash gas flow at the end of operation: GroupⅠ, the flow of oxygen maintained at 2 L/min, GroupⅡ 4 L/min, GroupⅢ 10 L/min. Anesthesia was induced with intravenous midazolam 0.08- 0.1mg/kg, etomidate 15- 20mg,fentanyl 3- 4 ?g/kg, pipecuronium 0.08- 0.1mg/kg and maintained with Enflurane(1.5- 2.0vol%), supplemented with intermittent iv pipecuronium and fentanyl. The concentration of Enflurane was monitored continuous which involved Fi, Fa and Fao, originated from inspiration, expiration and the moment expiration when stopped inhalation. Accounted Fao and after this detailed every one minute Fa until the patients recovery and calculated Fa/Fao ratio. Emergence time was recorded. Mini- Mental State Examination (MMSE) was performed before anesthesia and after surgery. Results: Fa/Fao ratio in GroupⅠ was significantly defferent from GroupⅡ and Ⅲ. MMSE scores in GroupⅠwere higher compare with GroupⅡand Ⅲ after surgery. Emergence time was no signif-icantly difference among three groups. Conclusion : The frash gas low flow of oxygen ventila-tion might reduce the incidence of delirium,but does not influnce the time of emergence from general anesthesia.