Budesonide nebulization in the treatment of neonatal ventilator associated pneumonia

Objective: To investigate the clinical effect of budesonide nebulization in the treatment of ventilator associated pneumonia of newborns and its safety

Methods: Forty-five newborns who had ventilator associated pneumonia and were admitted into the Binzhou People's Hospital between May 2014 and May 2015 were selected and included as an observation group. Moreover, another forty-five newborns who had ventilator associated pneumonia but did not undergo budesonide treatment in 2014 were randomly selected and included as a control group. Patients in the observation group were given budesonide suspension nebulization in addition to the conventional treatment. The evaluation indicators for therapeutic effect were compared between the two groups. The changes of head circumference, height and weight and death rate were observed by follow up after treatment

Results: The mechanical ventilation time, time for recovering from chest X-ray scan and hospitalization time of patients in the observation group were shorter than that of the control group, and the difference had statistical significance [P<0.05]

The oxygen index of the patients in the observation group was significantly improved compared to that of the control group, and the difference had statistical significance [P<0.05]. Patients in the two groups were followed up for six months after discharge. The head circumference, height and weight of the patients in the observation group in the 3[rd] and 6[th] month were compared to those of the control group, suggesting no significant differences [P>0.05]

The cumulative death rate of the observation group in the 6th month after treatment was significantly lower than that of the control group, and the difference had statistical significance [P<0.05]

Conclusion: Treating ventilator associated pneumonia of newborns with budesonide nebulization can effectively shorten mechanical ventilation time, time for recovering from chest X-ray scan and hospitalization time, improve pulmonary diffusion function and reduce the death rate, without affecting the growth and development of patients in the future

The expression and clinical significance of matrix metalioproteinase-2 and matrix metalloproteinase-9 in cervical cancer / 中国综合临床

Objective To sdudy the expression and clinical significance of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in cervical cancer.Methods Fifty-seven cases patients with cervical cancer who were treated in Hexigten Banner Hospital of Chifeng from January 2008 to December 2013 were selected as the observation group,and 23 patients with uterine benign lesion parallel hysterectomy were diagonosed by pathological diagonosis and selected as the control group.The positive expressions of MMP-2 and MMP-9 were observed and compared between observation group and control group.The correlation of MMP-2 and MMP-9 with clinical patholo gical factors were analyzed in cervical cancer patients.Results The positive expression rate of MMP-2 in observation group was 73.7％(42/57),significantly higher than that in the control group (21.7％ (5/23),P =0.032).The positive expression rate of MMP-9 in observation group was 61.4％ (35/57),significantly higher than that in control group (26.1％ (6/23),P =0.046).There were no significant differences between the expression of MMP-2,MMP-9 with the patient's age,the tumor chnical staging,the pathological type,the degree of differentiation and the diameter of tumor(P＞0.05),while the positive expression of MMP-2 and MMP-9 in patients with lymph node metastasis was higher than that in patients without lymph node metastasis(P =0.048,0.031).There was positive correlation between the expression of MMP-2 and MMP-9 (r =0.89,P＜0.05).Conclusion The expression of MMP-2 and MMP-9 in cervical cancer is higher than that in benign lesion,and the positive expression of MMP-2 and MMP-9 in patients with lymph node metastasis is higher than that in patients without lymph node metastasis,which indicate that the expression of MMP-2 and MMP-9 may play an role in the occurrence and development of cervical cancer,and associate with the invasion and metastasis of cervical cancer.

Dynamic Analysis of Bacteria Content in Air in Processing of Spine Operating / 中华医院感染学杂志

OBJECTIVE Researching the dynamic changes of air bacteria content in the process of spine operating.METHODS Adopt settling process to monitor the bacterium content of the air in the process of surgery operating at the point of pre-operating,cut skin,surgical sutures,suturescontent.RESULTS There are two obvious peak values of bacteria content in the process of spinal surgery operating,at beginning of operating and operating finished.CONCLUSIONS There are two obvious peak values of bacteria total amount changes in the process of operating in operating room,the main factor of the bacteria total amount changes in the air is the personal activities in operating room during operatings.