Study of electron-microscopic changes in the ethmoid sinus mucosa in patients with chronic sinusitis intraoperatively and six months after endoscopic sinus surgery

This study was designed to compare the intraoperative and six months postoperative Electron-Microscopic [EM] changes of Paranasal Sinus [PNS] mucosa in patients treated with Functional Endoscopic Sinus Surgery [FESS] for chronic sinusitis. Seventeen patients undergoing functional endoscopic sinus surgery for the treatment of chronic sinusitis with or without sinonasal polyposis were involved. The ethmoid sinus mucosa was sampled during operation and six months after surgery. The ciliated epithelium of the sinus mucosa was evaluated with transmission electron microscopy. Intraoperative specimens of the ciliated epithelium of the sinus mucosa of the patients showed abnormal architecture and degenerated ultrastructures. Postoperatively, normal architecture and ultrastructure of the ciliated epithelium was restored in most of the patients [n=13], few patients [n=4] showed persistent ulrastructural changes in their ethmoid sinus mucosa after FESS; these patients also showed mucosal changes and persistent radiological abnormalities in CT scan studies. These observations showed that unlike other conventional surgical procedures involving the sinonasal tract, paranasal sinus mucosa can regenerate and the ciliated epithelium can restore its normal structures after proper functional endoscopic sinus surgery and proper postoperative treatment. Persistent degenerative changes were found mostly to result of incomplete procedures and/or inadequate postoperative treatment

study of the possible hazards of acute and chronic exposure to microwaves on hepatorenal function and some blood trace elements in albino rats

Microwave exposure possess some degree of health hazards, the objective of the present study was the investigation of the possible effects of acute and chronic exposure to radiation on some liver, kidney, tissue antioxidants enzymes as superoxide dismutase, glutathione peroxidases, glutathione and toxic free radical lipid peroxide that results from stress oxidative tissues damage as well as the effect of microwaves on some trace elements that acts as metalloenzyme as zinc, selenium, copper and manganese. The result of the present study showed that exposure to microwaves [acute and chronic] produced significant reduction of antioxidant enzymes as superoxide dismutase, glutathione peroxidase and glutathione content. It also produced significant increase in toxic free radical malondialdehyde. These changes are more manifested with acute exposure [7 days]. The parameters of this study were improved with concomitant administration of DDB [well known antioxidant and tissue protective]. Also, the results showed that there was significant impairment of liver and kidney parameters with acute exposure and still there were changes in chronic which were insignificant. The parameters of liver and kidney were improved by the administration of DDB concomitantly