Effect of vanadium, radish and dill on some nutritional and biochemical parameters in diabetic rats

The present study was designed to investigate the effect of the vanadium pentaoxide and vegetables rich source in nadium as dill and radish on the nutritional status, some biochemical parameters and the histology of pancreas on streptozotocin induced diabetic rats. Forty-eight adult male rats, weighing 115 +/- 8 g rats were classified into control group and seven streptozotocin induced diabetic rat groups [untreated, treated with high, low vanadium, radish, dill, and low vanadium with dill or with radish groups]. The results revealed that, the untreated diabetic rat groups had a significant lower values of the final body weight, weight gain and its percentage, food intake, FER, insulin, triglyceride, AST/ALT ratio, total protein, globulin and HDL-c but significant increase in glucose, cholesterol, TG, LDL-c, urea and creatinine when compared with control group. The consumption of low vanadium with dill or radish to diabetic rat groups showed non significant difference in final body weight, weight gain and its percentage. food intake- FER, hemoglobin, PCV, cholesterol, TG, LDL-c, HDL-c, total protein, globulin, urea and creatinine, AST and ALT when compared with control group. Compared with untreated diabetic rats group, there were a significant increase in final body weight, weight gain, food intake, food efficiency ratio and globulin but significant decreased in cholesterol, LDL-c, urea and creatinine in all treated rats groups. Triglyceride increased in dill and radish groups. HDL-c decreased in dill group. High vanadium and low vanadium with dill or radish treated groups showed significant decreased in ALT and significant increased in AST/ALT ratio and total protein. There was non-significant difference in hemoglobin, packed cell volume, glucose, insulin and albumin among all treated rats group.lt is concluded that vanadium and its natural sources as dill or radish have hypoglycemic effect and beneficial for diabetic cases

relation of antioxidants and sodium nitrite on the oxidation reduction system and reproductive ability of male rats

A total of forty-nine Sprague -Dawley adult male rats administered standard diet with sodium nitrite and randomly classified into control and six treated rat groups which consumed vitamin C, vitamin E, and selenium,or selenium with vitamin C, vitamin E and both vitamins C and E. The study was assigned for eight weeks. Blood hemoglobin and packed cell volume, and also serum [LPX], [GPX], [SOD] and testosterone hormone as well as testis LPX, GPX, zinc, cupper and iron were also estimated. Testis of male rats were histopathologicaly examined. It was found that addition of vitamin C or E and selenium could significantly increase the final body weight, body weight gain and FER when compared with control group. The consumption of combination of vitamin C, E and selenium had the highest values of hemoglobin and packed cell volume when compared with control group. The mean values of serum [LPX] were significantly decreased in rat groups which treated with vitamin C or E or selenium [1st, 2nd, 3rd groups] and appeared highly significant decreased in rat groups which consumed selenium with vitamin C or E or both of them while the values of [GPX] were highly significant increased in all treated rats groups but the value of [SOD] was non significant difference in the 1st group when compared with control group. The value of testis LPX was significantly decreased but testis [GPX] were significantly increased in all treated rat groups when compared with control group. The mean values of testis zinc were significantly increased in all treated rat groups except rat groups which consumed vitamin E or selenium while copper values were significantly increased in 4th, 5th and 6th rat groups but iron values were significantly decreased in all treated rat groups when compared with control group. Testis of control group showed degeneration of testis cells but consumption of vitamin C and E showed slight degeneration of testis cells while consumption of selenium, in addition of vitamin C or E or both showed normal histological structure of testis cells. In conclusion, the administration of combination of antioxidants of vitamins C and E and selenium can lower the side effects of NaNO2 and improve the healthy status of testis with increase of reproductive ability