Synthesis and mass spectra of some aryl aldehyde thiosemicarbazones

The reaction of ethyl beta-aryl-alpha-cyanoacrylate [1] with thiosemicarbazide in the presence of potassium carbonate gave arylaldehydethiosemicarbazone [3]. Treatment of compound 3 with acetic anhydride, benzoyl chloride and ethyl chloroacetate yielded the corresponding 4-[substituted benzaldehyde-2, 4-diacetytl hiosemicarbazone] [4], 4 [substituted benzaldehyde -2, 4-dibenzoyl thiose micarbazones] [5], and 3-substituted-2-thioxo-imidazolidin-4-one [6]. The mass spectral fragmentation patterns of the compounds 3, 4, 5 and 6 are described

Synthesis and reactions of 2- [2, [2, 4, 6-trimethyl benzoyl] Vinyl] -4H-3, 1-benzoxazin-4-one of expected biological activity

Beta-[2,4,6-trimethyibenzoyl]- acryloyl chloride reacts with anthranilic acid to give [1] which is easily cyclized by the action of acetic anhydride to give the Benzoxazone[2]. Condensation of [2] with hydrazine hydrate give [3]. The behaviour of [3] towards the action of aromatic aldehydes, ketones, phthalic anhydride and phthalyl amino acid chlorides has been investigated. Reactions of [2] with o-phenylene diamine, ammonia, grignard reagents, friedl-crafts reaction and bomine has been described