RESUMO
The present study was undertaken to assess the effect of stat dose of oral prednisolone on rate of hospitalisation in patients of acute bronchial asthma. 259 patients, aged 1-65 years presenting with acute exacerbation of asthma were randomised in a double blind fashion to receive a stat dose of oral prednisolonev (30 mg if age < 5 years; 60 mg if age > 5 years) or equivalent placebo. Then, nebulbutamol (0.15 mg/kg in 2 m/l normal saline) was given to all patients and patients were re-examined after 4 hours to decide about the hospitalisation. The study revealed that only 37 (26.42%) patients required hospitalisation and further management in prednisolone group compared to 50 (42.01%) patients in placebo group (p < 0.01). This suggests that prompt use of single oral dose of prednisolone along with routine bronchodilator therapy can significantly reduce morbidity and need for hospital admission in patients of acute bronchial asthma.
Assuntos
Administração Oral , Adolescente , Adulto , Idoso , Anti-Inflamatórios/uso terapêutico , Asma/tratamento farmacológico , Criança , Pré-Escolar , Relação Dose-Resposta a Droga , Método Duplo-Cego , Feminino , Hospitalização/estatística & dados numéricos , Humanos , Índia , Lactente , Masculino , Pessoa de Meia-Idade , Prednisolona/administração & dosagem , Resultado do TratamentoRESUMO
Effect of pretreatment of intraperitoneally administered Ca-channel blockers Nifedipine (5, 10, 20 mg/kg). Verapamil (5, 10, 20 mg/kg) and Diltiazem (5, 10, 20 mg/kg) was studied on Haloperidol-induced catalepsy and Methamphetamine-induced stereotypy in albino rats. All these drugs reduced the onset of catalepsy, significantly increased the cataleptic score and delayed the onset and inhibited the Methamphetamine-induced stereotypy. The possible involvement of dopaminergic and adrenergic mechanisms and modification by Ca-channel blockers are discussed.