RESUMO
<p><b>OBJECTIVE</b>To identify the prevalence and risk factors of diabetes and prediabetes in the community residents above 18 years old in the suburbs of Guangzhou.</p><p><b>METHODS</b>Between April and May in 2008, the residents above 18 years living in 6 communities of Guangzhou for 5 or more years were sampled with multistage clustering sampling. The sampled residents were surveyed by questionnaires, and physical examination and glucose determination were carried out.</p><p><b>RESULTS</b>A total of 1532 residents were sampled. The incidence of diabetes mellitus in these community residents was 8.46%, and that of impaired glucose regulation was 6.59%. Age, body mass index, family history of diabetes mellitus, case history of hypertension, hyperlipidemia, hypertension and smoking were all the independent risk factors for impaired glucose regulation and diabetes mellitus.</p><p><b>CONCLUSION</b>Diabetes and prediabetes are prevalent in the community residents in Guangzhou. Controlling the risk factors such as obesity, hypertension, lipid metabolism disorder among the residents above 40 years with a family history of diabetes mellitus and hypertension is key to prevention of impaired glucose regulation and diabetes mellitus.</p>
Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Glicemia , Metabolismo , China , Epidemiologia , Diabetes Mellitus Tipo 2 , Sangue , Epidemiologia , Estado Pré-Diabético , Sangue , Epidemiologia , Prevalência , Fatores de Risco , Saúde Suburbana , Inquéritos e QuestionáriosRESUMO
Ocean is a unique and excellent resource that provides a diverse array of intriguing natural products. Marine natural products have demonstrated significant and extremely potent biological activities and have captured the attention of natural products chemists in the past few decades. It is increasingly recognized that a wealth of fascinating natural products and novel chemical entities will play a dominant role in the discovery of useful leads for the development of pharmaceutical agents and provide useful probes to lead to breakthroughs in a variety of life-science fields. This article focused on the research progress of chemistry of marine natural products in recent five years.
Assuntos
Animais , Humanos , Alcaloides , Química , Farmacologia , Anti-Infecciosos , Química , Farmacologia , Antineoplásicos , Química , Farmacologia , Organismos Aquáticos , Química , Produtos Biológicos , Química , Farmacologia , Macrolídeos , Química , Farmacologia , Biologia Marinha , Toxinas Marinhas , Química , Farmacologia , Estrutura Molecular , Peptídeos , Química , Farmacologia , Esteroides , Química , Farmacologia , Terpenos , Química , FarmacologiaRESUMO
<p><b>OBJECTIVE</b>To study the non-taxoids in the leaves of Taxus mairei.</p><p><b>METHOD</b>The chemical constituents were isolated by chromatography and identified by spectral data.</p><p><b>RESULT</b>Five compounds, taxamairin A (1), taxamairin B (2), sciadopitysin (3), ( - ) matairesinol (4), ponasterone A (5) were isolated and identified.</p><p><b>CONCLUSION</b>Compounds 3-5 were isolated from this plant for the first time, compounds 1 and 2 were isolated from the leaves of T. mairei for the first time.</p>