RESUMO
Effect of pretreatment of intraperitoneally administered Ca-channel blockers Nifedipine (5, 10, 20 mg/kg). Verapamil (5, 10, 20 mg/kg) and Diltiazem (5, 10, 20 mg/kg) was studied on Haloperidol-induced catalepsy and Methamphetamine-induced stereotypy in albino rats. All these drugs reduced the onset of catalepsy, significantly increased the cataleptic score and delayed the onset and inhibited the Methamphetamine-induced stereotypy. The possible involvement of dopaminergic and adrenergic mechanisms and modification by Ca-channel blockers are discussed.
Assuntos
Animais , Bloqueadores dos Canais de Cálcio/farmacologia , Catalepsia/induzido quimicamente , Depressores do Sistema Nervoso Central/farmacologia , Estimulantes do Sistema Nervoso Central/farmacologia , Diltiazem/farmacologia , Feminino , Haloperidol/farmacologia , Masculino , Metanfetamina/farmacologia , Nifedipino/farmacologia , Ratos , Ratos Wistar , Comportamento Estereotipado/efeitos dos fármacos , Verapamil/farmacologiaRESUMO
The effects of ranitidine (2 mg/kg, po) and phenylbutazone (100 mg/kg po) have been studied in different models of acute and chronic inflammation in rats. Ranitidine showed significant anti-inflammatory activity in the four models used. This observation supports the concept that histamine has a pro-inflammatory role that is mediated via stimulation of H2-receptors.
Assuntos
Doença Aguda , Animais , Anti-Inflamatórios , Artrite/tratamento farmacológico , Artrite Experimental/tratamento farmacológico , Carragenina , Doença Crônica , Feminino , Granuloma/tratamento farmacológico , Inflamação/tratamento farmacológico , Masculino , Peritonite/tratamento farmacológico , Ranitidina/uso terapêutico , Ratos , Ratos Endogâmicos , TerebintinaRESUMO
Anti-gastric activity of metoclopramide was studied in guinea pigs using three different models of gastric ulceration. The effect of metoclopramide on gastric acidity was also studied. It was observed that metoclopramide affords protection against all types of experimentally induced gastric ulceration, without affecting the gastric acid secretion. The protective effect, therefore, is probably due to its ability to promote gastric drainage and to prevent the pyloric reflux, thus preventing corrosive effects of bile and acid on the stomach mucosa.
Assuntos
Animais , Antiulcerosos , Aspirina , Relação Dose-Resposta a Droga , Feminino , Determinação da Acidez Gástrica , Cobaias , Histamina , Ligadura , Masculino , Metoclopramida/farmacologia , Pepsina A/metabolismo , Piloro/fisiologia , Úlcera Gástrica/tratamento farmacológicoRESUMO
The present work was undertaken to study and compare the gastric ulcerogenic action of analgesic antipyretic agents in guinea pigs. Their interaction with sodium salicylate was also studied. It was observed that aspirin, both microfined and ordinary, phenylbutazone, indomethacin and sodium salicylate were highly ulcerogenic in guinea pigs, while paracetamol and ibuprofen did not exhibit this action. It was also observed that sodium salicylate did not modify the ulcerogenic action of aspirin (both ordinary and microfined), phenylbutazone, ibuprofen and paracetamol but antagonized significantly the ulcerogenic action of indomethacin.
Assuntos
Animais , Anti-Inflamatórios não Esteroides/toxicidade , Interações Medicamentosas , Feminino , Ácido Gástrico/metabolismo , Cobaias , Masculino , Ácido Salicílico , Salicilatos/toxicidade , Úlcera Gástrica/induzido quimicamenteAssuntos
Doença Aguda , Animais , Ansiolíticos/uso terapêutico , Feminino , Ligadura , Masculino , Ratos , Úlcera Gástrica/tratamento farmacológicoAssuntos
Doença Aguda , Animais , Estradiol/uso terapêutico , Feminino , Cobaias , Masculino , Progesterona/uso terapêutico , Ratos , Úlcera Gástrica/etiologiaRESUMO
Stress ulcers were induced by subjecting rats to forced immobilisation and cold (4 degrees to 7 degrees C) for 4 hrs. The nature of drugs which afford varying degrees of protection against such ulceration, bring out the complexity of the factors involved in the study of pathogenesis of acute gastric ulceration due to stress.