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1.
The Korean Journal of Physiology and Pharmacology ; : 95-100, 2011.
Artigo em Inglês | WPRIM | ID: wpr-727372

RESUMO

DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no molecular mechanism has yet explained how protein levels of DREAM are regulated. Here we identified group I mGluR (mGluR1/5) as a positive regulator of DREAM protein expression. Overexpression of mGluR1/5 increased the cellular level of DREAM. Up-regulation of DREAM resulted in increased DREAM protein in both the nucleus and cytoplasm, where the protein acts as a transcriptional repressor and a modulator of its interacting proteins, respectively. DHPG (3,5-dihydroxyphenylglycine), a group I mGluR agonist, also up-regulated DREAM expression in cortical neurons. These results suggest that group I mGluR is the first identified receptor that may regulate DREAM activity in neurons.


Assuntos
Cálcio , Citoplasma , Dinorfinas , Metoxi-Hidroxifenilglicol , Neurônios , Canais de Potássio , Presenilinas , Proteínas , Receptores de Glutamato Metabotrópico , Regulação para Cima
2.
Journal of Rheumatic Diseases ; : 55-59, 2011.
Artigo em Coreano | WPRIM | ID: wpr-104645

RESUMO

Infliximab is a chimeric mouse/human monoclonal antibody against tumor necrosis factor-alpha (TNF-alpha) that is used worldwide to treat rheumatic disease. However, the reactivation of tuberculosis, including extrapulmonary menifestation, is a severe side effect of anti-TNF-alpha treatment. Mycobacterium tubercluosis causes two forms of joint involvement, TB arthritis and Poncet's disease. Poncet's disease is a rare aseptic form of arthritis, known as reactive arthritis in tuberculosis. We encountered a case of tuberculous peritonitis with Poncet's disease in a 38-yearold man with a history of ankylosing spondylitis that was treated with infliximab. We report this case with a review of the literature.


Assuntos
Humanos , Anticorpos Monoclonais , Artrite , Artrite Reativa , Articulações , Mycobacterium , Peritonite Tuberculosa , Doenças Reumáticas , Espondilite Anquilosante , Tuberculose , Fator de Necrose Tumoral alfa , Infliximab
3.
The Journal of the Korean Rheumatism Association ; : 110-116, 1999.
Artigo em Coreano | WPRIM | ID: wpr-157311

RESUMO

OBJECTIVE: To investigate the proliferative and anti-apoptotic effects of TGF-beta and IL-1beta on rheumatoid synovial cells. METHODS: Synovial cells obtained from surgical procedure of the rheumatoid joint were cultured with TFG-beta and IL-1beta The proliferative response of synovial cells was examined by non-radioactive cell proliferation assay. Fas-demiated apoptosis of synovial cells was measured by flow cytometry after addition of anti-Fas antibody. RESULTS: TGF-beta and IL-1betaproliferated synovial cells in a dose-dependent manner. They also made synovial cells resistant to anti-Fas antibody induced apoptosis. CONCLUSION: TGF-beta and IL-1betapromotes synovial cell proliferation possibly through interference with Fas-mediated apoptosis, suggesting their role in synovial hyperplasis in rheumatoid arthritis.


Assuntos
Apoptose , Artrite Reumatoide , Proliferação de Células , Citometria de Fluxo , Interleucina-1 , Interleucina-1beta , Articulações , Fator de Crescimento Transformador beta
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