Small-leaf Kuding Extract Decreases Hyperglycemia in Mice by Upregulating Nrf2 / INS Expression at the Protein Level / 中国生物化学与分子生物学报

In recent years, the prevalence of hyperglycemia has been increasing, and patients’ bodies have been seriously damaged. Compared with conventional Western drugs, natural products have fewer adverse reactions and delay the complications of hyperglycemia. As a valuable natural product resource, Small-leaf Kuding (SLK) contains various beneficial components for the human body. The aim of this study was to study the regulation effect of SLK extract at different doses on blood glucose metabolism in hyperglycemic mice. Lipopolysaccharide and streptozotocin were used to induce hyperglycemia in mice. Extract of SLK were administered intragastrically at low, medium, and high doses (5 g·kg

Subcutaneous implantation of embryonic skin cells to construct a model of hair development in nude mice / 南方医科大学学报

<p><b>OBJECTIVE</b>To observe the hair development after subcutaneous implantation of embryonic skin cells in nude mice, and construct a model of hair development.</p><p><b>METHODS</b>Dermal and epidermal cells isolated from embryonic mouse skin were mixed at a given ratio and injected subcutaneously in nude mice, and hair formation after the implantation was observed under a microscope.</p><p><b>RESULTS</b>Formation of the hair follicles and fibers under the skin of the recipient nude mice and emergence of the hair shaft were observed microscopically.</p><p><b>CONCLUSION</b>Embryonic skin cells be used to construct a complete model of hair development after implantation in vivo.</p>

Effects of different parts of the follicle-unit grafts subjected to controlled injury / 南方医科大学学报

<p><b>OBJECTIVE</b>To study the shaft elongation and morphological changes of follicle-unit (FUs) grafts subjected to controlled injury in different parts.</p><p><b>METHODS</b>Human FUs were isolated by microdissection under a dissecting microscope. The single hair of anagen FUs were randomly divided into A, B and C groups, and A and B groups were subjected to controlled injury with microsurgery imposed to the dermal papilla and the bulge of FUs, respectively, with C as the control group without any treatment. HE staining was used to detect the histological changes of the cells, and organ culture for 10 days was conducted to observe the morphological changes and elongation of FUs.</p><p><b>RESULTS</b>There were no histological or morphological changes in A, B and C groups. The average elongation of hair shaft was 1.293-/+0.245, 2.116-/+0.423 and 2.235-/+0.379 mm, respectively. There were significant differences between groups A and B (P<0.05) and between groups A and C (P<0.05). No significant difference was found between groups B and C (P>0.05).</p><p><b>CONCLUSION</b>Damage of the dermal papilla should be avoided in hair transplantation surgery.</p>