action of inositol hexanicotinate as antilipaemic on normal and hypercholesterolaemic rabbits

The effect of Inositol hexanicotinate [IHN] on serum lipid fractions and body weight was examined in both normal and induced-hypercholesterolaemic rabbits. Generally, Inositol hexanicotinate [IHN] slightly reduced the serum levels of lipid constituents: total triglycerides, phospholipids and total cholesterol. However, these fractions were significantly decreased in serum of the induced hypercholesterolaemic rabbits. The body weights as well as the alpha, Beta and non-mobilized-lipoproteins were also reduced in serum of the hypercholesterolaemic animals. The role of the examined drug as anticholesterolaemic and antilipaemic agent was discussed