possibility of transplacental transmission of experimental schistosomiasis

Congenital transmission of Schistosoma mansoni and S. hematobium in mice was studied by experimentally infected pregnant mice on day 3, 9 or 14 of gestation. None of the pups born to mothers infected in early or mid- pregnancy were infected. However, several pregnancies ended in abortion ranging between 10% to 40%. On the other hand, 8 out of 30 pups born to mice infected with S. hematobium in late pregnancy were found to harbor Schistosomes with granulomas recovered in their livers and intestines. These findings showed that congenital infection of mice with S. mansoni and S. hematobium could occur when pregnant mice were infected during late pregnancy. This may have important implications not only for mice but also for other mammalian hosts of Schistosomes including man

effect of flubendazole on the course of trichinella spiralis infection in mice: parasitological study

This work aimed to study the effect of flubendazole against different stages of Trichinella spiralis infection in mice. Three groups of experimental animals were examined: Control group, group I [treated 3 days post-infection] and group II [treated 4 weeks post- infection]. In group I, flubendazole was shown to be a very potent agent in killing Trichinella spiralis adults and larvae, when given orally in a dose of 20 mg/kg for 5 consecutive days. This is evidenced by the significant reduction in number, length of the female and reproductive capacity as well as the absence of the muscle larvae. However, in group II, the effect of the drug although still significant yet diminished in all parameters as compared with the early treatment. These results evoked ideas for further design of other treatment and control of disease