Histomorphological spectrum of Phyllodes Tumours: A Restrospective Study

Introduction: Phyllodes tumours are rare fibroepithelial lesions of breast. Clinical examina?on, ultrasound, cytology and histopathology are the mainstay of the diagnosis. The present research was undertaken with the aim of studying the clinicopathological features of Phyllodes tumour reported in the past seven years in a Delhi government hospital. Method: A retrospec?ve study of phyllodes tumour was carried out in females from 225 diagnosed cases of breast lesion reported in the pathology department of a government hospital in Delhi during the period of January 2013 to December2019. All the relevant history, findings of clinical examina?on and inves?ga?ons performed were assessed from files of the pa?ent. Results: Out of 225 cases of breast lesions reported in the pathology department 8 tumours were reported as phyllodes in the study period. The most common affected age group was 41- 50yrs. 5 (62.5 %) of 8 tumours were benign,2 (25) %) were borderline and only 1 was malignant. The tumour size was 15mm to 200mm. All the 8 cases (100%) presented with breast lump; 3 cases (30%) complained of pain in the lump. 2 cases developed ulcera?on and Peau D’ orange and in 1 case typical nipple retrac?on was seen. FNAC was done in 5 pa?ents. No preopera?ve inves?ga?ons were done in 2cases. Conclusion: Phyllodes tumour is a rare neoplasm of the breast. Histopathology plays an important role in differen?a?ng it from fibroadenoma. Strict histologic assessment is definitely required for the diagnosis of the PT and for its treatment and management

Clinicopathological study of dermolipoma--a report of four cases.

Dermolipomas are congenital solid choristomas usually located in the superotemporal fornix, near the lacrimal gland and lateral rectus muscle. Retrospective analysis of four consecutive cases of dermolipoma reported between Jan 1994 and July 2005 was done. Three cases were males and one was female and in all the cases swelling was first noted in the early childhood. Histologically they show squamous epithelium lined tissue containing mature adipose tissue in addition to bundles of dense collagen and adnexal structures which were present in all our cases. Surgical excision of dermolipoma is conservative and confined to the irritating dermal surface or the visible portion of the lesion.

Recurrent diffuse lipomatosis of the neck--a case report.

Diffuse lipomatosis is a rare disorder of adipose tissue occurring in young people . It has a predilection for trunk and proximal extremities where it presents as poorly circumscribed overgrowth of fatty tissue. Definite diagnosis is established by histological examination of tumor. Though it attains extensive size and has a high tendency to recur, the clinical course is benign.

Bone marrow trephine biopsy as an adjunct to bone marrow aspiration.

OBJECTIVE: To determine the relative efficacy of bone marrow aspiration as compared to that of trephine biopsy. METHODS: Bone marrow aspiration and bilateral trephine biopsies were performed in 420 consecutive cases. The diagnosis and findings made on bone marrow aspiration were compared with that made on trephine biopsy in each case. RESULTS: Aspiration alone was sufficient in making a diagnosis in 372 (88.6%) cases as it correlated well with the diagnosis made on trephine sections. In the remaining 48 (11.4%) cases trephine biopsy was necessary for making a diagnosis due to incomplete information provided by aspiration or its inability to give a correct diagnosis. These cases were mostly hypoplastic/aplastic marrow, myelofibrosis and marrow involvement by metastatic tumour and lymphomatous infiltration. Often a bilateral marrow biopsy picked up the diagnostic lesion. CONCLUSION: The decision to perform a marrow aspiration alone or in combination with marrow biopsy depends on the diagnosis being considered. In nutritional anaemias, most hematologic malignancies and immune thrombocytopenias, marrow aspiration alone is sufficient, but for detection of disorders with focal marrow involvement bilateral marrow biopsies are a must.