RESUMO
Acute renal failure induced by ischemia / reperfusion [I/R] causes excretory functional disorders of nephrons. The purpose of this study is to evaluate the intake of oral rosemary extract [gavage] on hemodynamic changes and tissue damages caused by I/R. This study was conducted on 40 Sprague-Dawley male rats, composed of 4 groups [n=10] including control, sham, I/R+normal saline [I/R+NS] posttreatment and I/R+rosemary [I/R+RO] post-treatment. They were fed with 10 ml/kg of 8% aqueous extract or vehicle as gavages during the first 48 hours after I/R. To induce I/R, both renal artery and vein were blocked for 30 minutes followed by a reperfusion within 48 hours. Then urine and plasma samples were collected and histological study was also conducted after removal of both kidneys. Data were analyzed by SPSS-11.5 software. The one-way analysis of variance [ANOVA] and Duncan test were used for intergroup comparison and p