Synthesis and analgesic activity of benzofuran carboxamide derivatives

Treating 4-methoxy- and 4,7-dimethoxy-6-hydroxybenzofuran-5-carboxylic acid with ethyl chloroformate in dry acetone leads to the formation of the monocarbethoxy derivatives, which on cyclization give the corresponding anhydrides. The latter compounds react with hydrazines to give the hydrazide carboxylate derivatives. On the other hand, when the benzofuran-5-carboxylic acids are treated with ethyl chloroformate in dimethyl formamide, the 5-carbethoxy derivatives are obtained. These react with hydrazine hydrate and amines. Some of the new compounds show analgesic activity

Pharmacological studies on some new pyrazolones

Some new synthesized pyrazolone derivatives were tested for their possible anti-inflammatory, analgesic, antipyretic and ulcerogenic action. Compounds [II] 3-[p-chlorophenoxy]-1, 2-di phenyl-3- pyrazolin-5-one and [III] 3-[2, 4-dichlorophenoxy]-1, 2-diphenyl-3- pyrazolin-5-one showed a significant anti-inflammatory and antipyretic effects. Tested compounds failed to demonstrate any significant analgesic effect while they were all ulcerogenic

Pharmaco-toxicological study on ammi majus seeds

The total alcoholic extract [I], coumarin [II] and glycosidic [III] fractions of Ammi majus seeds were studied from the toxic and pharmacological points of view. The acute LD50's of the extracts were 2925.6, 1197.7, and 570.48 mg/kg body weight respectively. The extracts produced significant decrease in the mean hemoglobin concentration, white blood cell count and lymphocytic count in white rate Ammi majus seeds given as 10% of the diet of rats for 6 months significantly increased then decreased the mean body weight and significantly decreased the hemoglobin concentration and total leucocytic count. I, II, III produced lowering of the arterial blood pressure and increase of the respiratory rate in dogs, decrease the amplitude of the frog's heart and inhibit the intestinal motility of rabbit intestine. I stimulated and II and III inhibited the isolated perfused rats uteri at different stages of sex Cycle

Some hepatotoxic and reproductive effects of vincristine sulphate and doxorubicin chloride in normal and liver damaged male rats

Vincristine sulphate [I] and doxorubicin hydrochloride [II] in large doses for short time increase significantly serum liver enzymes in both young and aged rats. Smaller doses from each and both in combination failed to affect liver enzymes of young rats, also smaller doses from all treatments for 21 days failed to affect liver enzymes of young and liver damaged rats. Smaller or larger doses for short or long periods significantly affected liver enzymes of aged rats. [I] in large or small doses did not affect the sperm quality or internal organs, while [II] significantly affected sperm quality when given alone or with [I] in all conditions

Effects of oral administration of vicince and convicine isolated from fava beans [vicia fabal] on the reproductive system and apeen quality of maid mice

Daily oral administration of 5 mg/25 g body weight glycosides vicine and convicine for two weeks in male mice caused significant increase in seminal vesicle and vas deferens weight while there was no change in the weight of the prostate. Concerning the effect on semen quality, there were an increase in the percent of abnormal sperm and decrease in the percent of motile sperm. Histopathological findings revealed areas of degenerations appeared in the transverse section of the testes where edema present, seminiferous tubules showed arrest of spermatogenesis. The results of this study demonstrated that vicine and convicine when given to male mice have a prominent effect on the reproductive organs as well as the spermatogenesis

Effect of hibiscus sabdarifla on the blood picture, sperm quality and genital organs of rats

Oral administration of water extract of Hibiscus sabdariffa flowers [20 mg/100 gm body weight] daily for 8 weeks to male albino rats produces increase in total leucocytic count, haemoglobin percent and lymphocytes after 4-8 weeks, in the mean time the neutrophils decreases after 4 weeks. The increase in the percentage of motile sperms and the increase of abnormal sperms were observed after 4 to 8 weeks of experiment. The extract also causes decrease in body weight and epididymis. However, the reduction in weight starts from the 4[th] to the 8[th] week of treatment. All the effects obtained were found to be reversible after discontinuation of treatment

Some pharmacological and toxicological studies on some food by-products

Oral and intraperitoncal administration of fooder yeast [I], Proteolain [II] and Rootlets [III] decoctions in mice showed no toxic effects in doses up to 3 gm/100 gm body weight. The three extracts inhibited the isolated frog's heart. I and III inhibited the other hand I significantly decreased the haemoglobin conhibited also the intestinal activity of the isolated rabbit's intestine. Feeding the three extracts for six months as 10% of the diet to rats showed that, II and III produced to toxic effects on, the other hand I significantly decreased the haemoglobin Concentration and packed cell volume

Toxicity and teratogenicity of abrin

The toxicity of the purified isolated toxic protein [Abrin] from Abrus precatorius L, seeds was determined. The acute LD[50] +/- Fid. L. of Abrin intraperitoneally injected in mice was found to be 8.34 +/- 1.3 mg/Kg. A heat labile haemagglutinating effect was demonstrated and was found to be 1290 Hu/g Abrin. Prolonged administration of Abrin in mice produced initial anemia which normalises at the end of the experiment, also it produced significant increase in white blood cell count all over the course of the experiment. intraperitoneal injection of Abrin to pregnant rats produced significant maternal and fetal changes, while Abrin po. produced significant fetal effects only

Evaluation of some drug solvents for teratological investigation in rats

Female rats were treated by oral administration of 0.2 ml. of 10% solution of propylene glycol in distilled water or by 0.2 ml. olive oil. These doses were found to have no toxic effects on rats [El-Shabrawy, 1980]. Treatments were put to fulfill pre-mating and/ or during pregnancy exposure of animals to propylene glycol or olive oil. Significancy reduction in postnatal body weights was found in offspring from females treated with olive oil before mating and continued during the 1[st] 10 days of pregnancy. Non-significant results indicative of maternal toxicity, embryotoxicity or teratogenicity were obtained in any of the treated groups