RESUMO
Background: Antibiotic Resistance has now become a big threat as antibiotics are no more useful now a days, as they were previously. The objective of this study was to analyse the various bacterial isolates found in Urinary Tract Infection. Methods: This Retrospective study was conducted in the department of Microbiology in collaboration with the department of Pharmacology of Pacific Medical College and Hospital, Udaipur, Around 705 culture proven urine isolates were retrospectively studied. The samples were collected during one year from both the inpatient as well as the outpatient department of Pacific Medical College and Hospital, Udaipur. Results: Uropathogenic strains from inpatient and outpatient departments were studied for their susceptibility profiles. The various isolates were Escherichia coli, Klebseilla pneumoniae, Pseudomonas aeruginosa. Antibiotic susceptibility pattern of these isolates revealed that for outpatients, first generation Cephalosporins, nitrofurantoin, Norfloxacin/ciprofloxacin were effective for treatment of urinary tract infection but for inpatients, parenteral therapy with newer aminoglycosides and third generation Cephalosporins should be administered as the organisms for nosocomial UTI exhibit a high degree of drug resistance. Conclusion: Culture and sensitivity of the isolates from urine samples should be done as a routine before starting the antimicrobial therapy.
RESUMO
Background: The objective of this study was to analyse the prescribing pattern of NSAIDs in patients attending Orthopaedics OPD and to analyse the correlation between the use of selective COX-2 inhibitors and older conventional NSAIDs in the pattern of current practice. Methods: This Prospective study was conducted on Patients visiting Orthopaedics OPD of Pacific Medical College and Hospital, Udaipur, during 6 month study period. Individual data was collected in a preformed format and was analyzed on parameters such as demographic profile and NSAID's usage pattern. Results: 180 patients were selected on the basis of inclusion and exclusion criteria. Around 417 drugs were prescribed, out of which 302 were oral, 39 were topical (Table No.2). Out of 417 drugs, total number of systemic NSAID's used were 302 [72.2%]. Of these 185 (56.2%) were used as monotherapy and 144 (43.7%) were used as fixed dose combinations (FDC). Among monotherapy 103 (55.68 %) were non-selective and 82 (44.32 %) were selective COX inhibitors. Conclusion: The result of this study suggests that the frequent use of selective COX-2 inhibitors although conventional non-selective NSAIDs topped the list of various selective and non-selective NSAIDs. Concomitant gastro protectives were also used. Fixed dose combinations were also prescribed.