Isolation of antileishmanial, antimalarial and antimicrobial metabolites from Jatropha multifida

Objective: To investigate the antileishmanial, antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine. Methods: The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses to obtain three known metabolites, microcyclic lathyrane diterpenoids (1-3). Structures were confirmed by comparison of 1D and 2D spectral data with literature. Results: The three compounds exhibited inhibition of antileishmanial, antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC

Isolation of antileishmanial, antimalarial and antimicrobial metabolites from Jatropha multifida

Objective: To investigate the antileishmanial, antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine. Methods:The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses to obtain three known metabolites, microcyclic lathyrane diterpenoids (1-3). Structures were confirmed by comparison of 1D and 2D spectral data with literature. Results: The three compounds exhibited inhibition of antileishmanial, antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC50 of 8.2 and 8.7 μg/mL, respectively. Conclusions: The research lends support to the ethnomedicinal use of the plant in combating microbial infections, leishmaniasis and malarial infections.

Medicinal uses, phytochemistry and pharmacology of Picralima nitida (Apocynaceae) in tropical diseases: a review

Picralima nitida Durand and Hook, (fam. Apocynaceae) is a West African plant with varied applications in African folk medicine. Various parts of the plant have been employed ethnomedicinally as remedy for fever, hypertension, jaundice, dysmenorrheal, gastrointestinal disorders and malaria. In order to reveal its full pharmacological and therapeutic potentials, the present review focuses on the current medicinal uses, phytochemistry, pharmacological and toxicological activities of this species. Literature survey on scientific journals, books as well as electronic sources have shown the isolation of alkaloids, tannins, polyphenols and steroids from different parts of the plant, pharmacological studies revealed that the extract or isolated compounds from this species posses analgesic, anti-inflammatory, hypoglyceamic, hypotensive, antiplasmodial, antimicrobial, antiulcer and antitumorigenic activities. Results from various scientific investigations to date have revealed the potential of the extract from the plant or isolated compounds for use in the treatment and prevention of various kinds of human diseases. However, further studies on the extracts and pure compounds from this species is required to completely assess its phytochemical, pharmacological and toxicological profile as well as the mechanism of action behind these pharmacological activities exhibited by the compounds isolated from this species.

Isolation of antileishmanial, antimalarial and antimicrobial metabolites from Jatropha multifida

<p><b>OBJECTIVE</b>To investigate the antileishmanial, antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine.</p><p><b>METHODS</b>The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses to obtain three known metabolites, microcyclic lathyrane diterpenoids (1-3). Structures were confirmed by comparison of 1D and 2D spectral data with literature.</p><p><b>RESULTS</b>The three compounds exhibited inhibition of antileishmanial, antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC50 of 8.2 and 8.7 µg/mL, respectively.</p><p><b>CONCLUSIONS</b>The research lends support to the ethnomedicinal use of the plant in combating microbial infections, leishmaniasis and malarial infections.</p>