RESUMO
<p><b>OBJECTIVE</b>To investigate the effect of different preparation method on the quality of Shen-mai injection.</p><p><b>METHOD</b>The Shen-mai injection samples were prepared using three different methods. Fingerprints of Shen-mai extracts red ginseng, and its intermediates were obtained using an HPLC analytical procedure. The contents of ginsenoside Rg1, Rc and Rb1, and the gross saponins of Shen-mai extract were quantitatively mensured with HPLC procedures.</p><p><b>RESULT</b>There was significant difference in fingerprints and chemical contents of the injections prepared by the three different methods.</p><p><b>CONCLUSION</b>The quality of Shen-mai injection was greatly influenced by the preparation method. HPLC fingerprinting method can be applied for the determination of the Shen-mai preparations.</p>