RESUMO
This report describes for the first time the effect of hyperbaric oxygen therapy at 253 kPa on post-trauma acute compartment syndrome in 24 patients and the relationship between the prognosis of the syndrome and the changes of plasma fibronectin.Plasma fibronectin was measured using single radial immunodiffusion before and after the therapy and 30 healthy subjects were used as controls.The results showed that clinical symptoms and signs of 16 patients with acute compartment syndrome at the early stage were significantly improved after 3-5 times of hyperbaric oxygen therapy and recovered without performing fasciotomy; infection, edema and swelling of the injuried limbs and temperature were markedly reduced in 6 patients treated with hyperbaric oxygen after fasciotomy, and no good therapeutic efficacy was obtained in 2 patients at the necrotic stage although their clinical symptoms and signs were partially improved.It was also found that plasma fibronectin concentrations were significantly increased in these patients after hyperbaric oxygen therapy.The mean increase was 47(18.9%, P
RESUMO
To evaluate the changes of cellular immunity and relationship between cellular immunosuppression and infection after fracture, we, examined delayed hypersensitivity response, lymphocyte transformation and leucocyte migration inhibition index in 25 dogs.It was found that delayed hypersensitivity response to DNCB,, lymphocyte transformation to phytohemagglutinin and leucocyte migration inhibition index were significant- ly decreased l to 7 d after fracture in comparison with the control before fracture.The function of cellular immunity was restored two weeks later in the uninfected dogs, but it was not restored in dogs with osteomyelitis even 30 d after fracture.The results suggest that traumatic fracture can impair host cellular immunity.Continual cellular immunosuppression renders the host more susceptible for bacteria and results in infectious complications.Cellular immune indices can be used as valuable ones to pievent and reat infectious complications post-fracture.