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Background: Patients with Coronavirus Disease (COVID-19) have a significant death rate due to comorbid diseases. As a result, identifying risk factors associated with poor outcomes in COVID-19 patients is important. Objective: The aim of this study was to evaluate the admission and outcome status of the patients confirmed with Covid-19.Material & Methods:This cross-sectional study was conducted at Mugda Medical College & Hospital, Dhaka, Bangladesh during the period from April 2020 to September 2020. Total 205 patients with covid-19 were included in this study. Collection of data were checked and cleaned. After cleaning, the data were entered into computer and statistical analysis of the results being obtained by using windows-based computer software devised with Statistical Packages for Social Sciences version 24.Results:In this study among 205 patients. Most of the study people 41(20.0%) confirmed with covid-19 were admitted in September 2020. Followed by 20(9.76%) in April 2020, 33(16.09%) in May 2020, 35(17.07%) in June 2020, 38(18.53%) in July 2020, 37(18.04%) in August 2020 and 41(20.0%) in September. 23(11.21%) highest death with covid-19 were admitted in July 2020. Most of the patients 104(50.73%) were discharged with advice and 101(49.26%) patients had expired. Out of 101 expired patients 92 (91%) had comorbidities. The most common comorbidity amongst ICU admitted patients was respiratory syndrome (55 in number) and least common was hypertension (6 in number).Conclusions:The death rate for COVID-19 hospitalized patients is 49.26%. The most prevalent comorbidities in individuals who died as a result of COVID-19 were respiratory syndrome, chronic kidney disease, hypertension, cardiovascular disease, and diabetes.
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Abstract Rumex vesicarius hasbeen extensively used for the management of diabetes in the traditional system of medicine. The current study was designed to investigate antidiabetic and antihyperlipidemic effects of R.vesicarius and also to explore metabolomic profiling using UPLC-QTOF-MS. The effect of extracts was observed by checking the biochemical and histopathological parameters in diabetic rats. The results had shown a significant dose- dependent inhibition potential of aqueous extract of R. vesicarius seed against α-amylase and α-glucosidase along with significant inhibition in DPPH free-radical scavenging activity. Oral administration of R. vesicarius to diabetic rats significantly ( p< 0.05) ameliorated blood glucose level. It also improved the function of the liver and kidney as well as ameliorated dyslipidemia in diabetic rats. Histopathological examination of the treatment groups reversed the damage of the pancreas, liver, and kidney tissues confirming the antidiabetic efficacy of R. vesicarius. UPLC- QTOF-MS analysis of the extract revealed a total of 42 bioactive compounds, which might contribute to the antidiabetic activity. Based on our findings, we can conclude that R. vesicarius might be a promising candidate for the management of diabetes.
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Objectives: To prevent iron deficiency in pregnancy universal iron folic acid supplementation is recommended by WHO. We aimed to compare the effect of multiple micronutrients supplements with two different dosages of iron/folic acid supplements on maternal iron status. Methods: In the MINIMat intervention trial in Bangladesh, pregnant women were randomized into three micronutrient supplementation groups: 30 mg iron/400 ugfolic acid (Fe30 F), 60 mg iron/400 ugfolic acid (Fe 60 F) and multiple micronutrients +30 mg iron/400 ugfolic acid (MM). Adherence was electronically monitored by use of eDEM-pillbottles. Plasma-ferritin (p-Ft) was assessed at start of supplementation (week 14) and at week 30 at gestation in random subset. Intent to treat and multivariate regression analyses were performed (n=561). Results: Iron deficiency (ID) was 7% at start of supplementation. At wk 30 ID was 29% and mean p-Ft 20.0 ug/L with no differences according to supplementation type. Within each type there was a significant dose-effect per capsule on p-Ft that did not differ between types when amount of iron in the supplements was taken into consideration. There was no further dose-effect on p-Ft of iron intake exceeding 4 g. Using lowest tertile of iron intake as reference, middle and highest intake tertile increased p-Ft and showed a protective effect on ID at wk30 but did not differ between each other. Conclusions: Despite no further effect on p-Ft of higher iron intake than 4 g, ID developed to become prevalent at wk 30 suggesting that iron intake exceeding 4 g contributes to limited extent to reduce ID in pregnancy. Supplement with multiple micronutrients did not provide any additional effect.
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This study assessed the exposure of pregnant women to arsenic in Matlab, Bangladesh, an area with highly-elevated concentrations of arsenic in tubewells, by measuring concentrations of arsenic in urine. In a defined administrative area, all new pregnancies were identified by urine test in gestational week 6-8, and women were asked to participate in the assessment of arsenic exposure. Urine for analysis of arsenic was collected immediately and in gestational week 30. In total, 3,426 pregnant women provided urine samples during January 2002-March 2003. There was a considerable variation in urinary concentrations of arsenic (total range 1-1,470 microg/L, adjusted to specific gravity 1.012 g/mL), with an overall median concentration of 80 microg/L (25th and 75th percentiles were 37 and 208 microg/L respectively). Similar concentrations were found in gestational week 30, indicating no trend of decreasing exposure, despite the initiation of mitigation activities in the area. Arsenic exposure was negatively associated with socioeconomic classes and achieved educational level. There were marked geographical variations in exposure. The results emphasize the urgent need for efficient mitigation activities and investigations of arsenic-related reproductive effects.