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Indian J Physiol Pharmacol ; 1979 Apr-Jun; 23(2): 115-20
Artigo em Inglês | IMSEAR | ID: sea-107457

RESUMO

Toxicological study was carried out in rats with chloroform-soluble fraction of the nuts of Semecarpus anacardium to determine its safe non-toxic dose. The fraction produced toxicity at all levels tested (50-400 mg/kg) but the extent of toxicity was found dose-dependent. At lower doses this fraction induced partial growth inhibition over 36 days and higher doses proved fatal within 6 days. It was observed that 230 mg/kg caused 50% mortality in rats and this value is 1380 mg/m2 when expressed for body surface area. This work will be of some use in the cancer chemotherapy study of the fraction.


Assuntos
Animais , Comportamento Animal/efeitos dos fármacos , Peso Corporal/efeitos dos fármacos , Dose Letal Mediana , Masculino , Nozes , Extratos Vegetais/toxicidade , Plantas Medicinais , Ratos , Fatores de Tempo
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