Clinical observation on efficacy of Ramulus Cinnamomi, Poria capsules combined with mifepristone in the treatment of hysteromyoma / 中国基层医药

Objective To observe the efficacy of Ramulus Cinnamomi , Poria capsules combined with mifepristone in the treatment of hysteromyoma .Methods 60 patients with hysteromyoma were treated with drugs ,and according to the outpatient number they were randomly divided into three groups .Ⅰgroup ( n=20) were orally given mifepristone in a dosage of 12.5mg once daily for three months.Ⅱgroup (n=20) were orally given Cassia Tuckahoe Capsule for three months ,and Ⅲ group ( n=20 ) were orally given Cassia Tuckahoe Capsule for three months after given mifepristone in a dosage of 2.5mg once daily for one month.The size of hysteromyoma,FSH,LH,E2 and P were detected before and after treatment .The changes of clinical symptoms and adverse drug reactions were observed . Results The size of hysteromyoma of Ⅰ group and Ⅲ group [(2.41 ±1.03)cm3,(2.69 ±0.97)cm3]reduced significantly(P<0.05).FSH,LH,E2 and P in blood of Ⅰgroup reduced significantly(P<0.05),which inⅡgroup and Ⅲ group had no statistically significant differences between before and after treatment ( all P >0.05 ) . Conclusion Mifepristone combined with cassia tuckahoe capsule in treatment of patients with hysteromyoma is better than those only using mifepristone or cassia tuckahoe capsule .This combination therapy is indicated for preoperative medication or perimenopausal patients for conservative treatment of hysteromyoma .

Direct gene transfer of nacked DNA encoding vascular endothelial growth factor into ischemic swine myocardium / 中国介入心脏病学杂志

Objective To investigate the efficacy of vascular endothelial growth factor (VEGF) gene therapy in coronary occlusion of animal Methods 19 swine underwent left thoracotomy followed by the ligation of left anterior descending coronary artery Constructed pcD 2/hVEGF 121 eukaryotic expression plasmid was directly injected into the swine myocardium RT PCR, immunohistochemistry of VEGF and factor Ⅷ related antigen were used to detect VEGF gene expression and biological effect Coronary angiography was done to evaluate collateral circulation of the occluded artery Results High levels of VEGF mRNA and protein expression were detected There was a significant increase in the number of capillaries when compared with control group Coronary angiography showed better collateral circulation in VEGF group Conclusion Direct injection of pcD 2/hVEGF 121 eukaryotic expression plasmid can transfect the myocardium and express VEGF protein This gene product can increase capillary number and enhance collateral circulation of the occluded coronary