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1.
Chinese Pharmacological Bulletin ; (12): 1061-1066, 2023.
Artigo em Chinês | WPRIM | ID: wpr-1013782

RESUMO

Aim To investigate the role and specific mechanisms of muscle factor Irisin in regulating the intracellular protective protein Sirtl and mitochondrial uncoupling protein 2 (UCP2) during myocardial hypoxia. Methods H9c2 cells were treated with CoC12 for 24 hours to construct an in vitro hypoxia model of myocardial cells. Six groups were divided in this experiment; control group (control), Irisin group (10 nmol • L

2.
Chinese Journal of Industrial Hygiene and Occupational Diseases ; (12): 479-482, 2006.
Artigo em Chinês | WPRIM | ID: wpr-311436

RESUMO

<p><b>OBJECTIVE</b>To explore the relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to radiation injury.</p><p><b>METHODS</b>In 1:1 case-control study, 113 abnormal chromosome workers exposed to ionizing radiation were selected as cases and 113 normal chromosome as controls who matched with case for sex, age (+/- 5 years), nation, type of work, the same or more but in 2 years work length and the same similar levels of the cumulative exposure radiation dose. Genotypes were analysed using PCR based restriction fragment length polymorphism techniques.</p><p><b>RESULTS</b>The frequency of XRCC1 26304TT allele in case group (18.58%) was significantly higher than that in control group (7.08%), with OR for radiation damage being 3.47 (95% CI 1.43 - 8.44, P < 0.05). No association was observed between XRCC1 G27466A and G28152A and susceptibility to radiation injury.</p><p><b>CONCLUSION</b>The mutation of XRCC1 C26304T is related with the susceptibility to radiation injury. The polymorphisms of XRCC1 G27466A and G28152A are not found to have association with abnormal chromosomes.</p>


Assuntos
Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos de Casos e Controles , Aberrações Cromossômicas , Reparo do DNA , Proteínas de Ligação a DNA , Genética , Frequência do Gene , Predisposição Genética para Doença , Genótipo , Reação em Cadeia da Polimerase , Polimorfismo de Fragmento de Restrição , Lesões por Radiação , Genética , Proteína 1 Complementadora Cruzada de Reparo de Raio-X
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