Effect of Ginseng and Angelica Sinensis Decoction(GASD) on Learning and Memory of Dementia Rat with Hippocampal Lesions Induced by Quinolinic Acid / 中草药

By one trial passive avoidance respense-step-down task and water maze spatial localizat　ion task, the effect of Ginseng and Angelica Sinensis Decotion (GASD)on pathological mod　els of the anmesia rat with hippocampal lesions induced by quiuolinic acid was studied. Re　sults suggest that GASD can improve learning aud memory deficiency in rats with bilateral hippocampal lesions after administration of quinolinic acid. The major mechanism of GASD may be related to the regulation of the glutamatergic fuuction and prevention of the neuro　toxicity of quinolinic acid

Effects of ginsenoside of stem and leaf in combination with choline on improving learning and memory of Alzheimers disease / 中国药理学通报

AIM To observe the synergical effects of ginsenoside of stem and leaf(GSL)in combination with choline on learning and memory of Alzheimers disease(AD). MEHODS AD animal models were made by damaging nucleus basalis of Meynert with quinolinic acid. One time training passive aviodance step-down and water-maze spatial localization task were used to observe the ability of learning and memory.RESULTS Treatment with combination of GSL(400 mg?kg -1 ?d -1 ,ig) and choline(200 mg?kg -1 ?d -1 ,ig) on AD rats decreased significantly the number of errors on step down (ig for 13 days) and the training times to reach the criterion on water maze (ig for 16 days). The effect of GSL in combination with choline was more remarkable than that of GSL or choline and proved no obvious difference compaired with that of 1,2,3,4-tetrahydroacridine (10 mg?kg -1 ?d -1 ,ig). Value Q was more than one after administrition of both GSL and choline. CONCLUSION GSL in combination with choline may synergically improve the impairement of learning and memory of AD.

EFFECTS OF GINSENOSIDES ON THE ACTIVITIES OF Ca~(2+)-ATPase & Mg~(2+)-ATPase IN RABBIT CEREBRUM IN VITRO / 中国药理学通报

The effects of saponins extracted from stems & leaves of Panax ginseng C.A.Meyer including the total ginsenoside ( GNS) , panaxad-iol saponin ( PDS ) & panaxatriol saponin ( PTS ) on the activities of Ca2+-ATPase & Mg2+-ATPase in rabbit cerebral microsomes were studied in vitro. It was found that GNS & PTS significantly inhibited the activities of Ca2+-ATPase & Mg2+-ATPase. The activity of Ca2+-ATPase was activated by PDS at the concentrations of 10 & 100mg/L, and it dramatically inhibited the activity of Ca2+-ATPase the concentration of 1000mg/L. Furthermore, the activity of Mg2+-ATPase was inhibited by PDS at the concentrations of 100 & 1000mg/L. Chlorpromazine ( 0 .35 & 0 .70 mmol/L ) possessed the inhibitory effects on the activities of both Ca2+-ATPase & Mg2+-ATPase.