Design and synthesis of some substituted acridine derivatives of anticipated antitumor activity

Four series of new acridine derivatives of anticipated antitumor activity have been designed and synthesized. The first series belongs to 4-substituted phenylhydrazinocarbonylmethyl 9-oxo-9,10-dihydroacridine-4-carboxylate 10a-h. The second series consists of phenylhydrazinocarbonylmethyl 9-[4-substituted phenyl]aminoacridine-4-carboxylate 12a-k, while the third series comprises 4-substituted phenylcarbonylmethyl 9-[4-substituted phenyl]aminoacridine-4-carboxylate 15a-k. The fourth one belongs to phenylcarbamoylmethyl 9-[4-substituted phenyl]aminoacridine-4- carboxylate 17a-j. The chemical structure of synthesized compounds was elucidated by spectral data and elemental analysis. Seventeen selected compounds [10a, 10g, 10h, 12at 12d, 12g, 12h, 12k, 15a, 15c, 15g, 15h, 15k, 17a, 17f, 17g and 17j] were tested against breast cancer cell line [MCF7] and eight compounds [12g, 12h, 12k, 15g, 15h, 17f, 17g, 17j] were found to exhibit significant antitumor activity

Synthesis, molecular modeling and antitiumor activity of some substituted acridine derivatives

Nine series of new acridine derivatives of anticipated antineoplastic activity were synthesized. The first series consists of N,N'-1, 2-bis [9-[4-substituted sulfamoylphenyl] amino-acridine-4-carboxamide] ethylenediamine. The second comprises of N,N'-1,4-bis [9-[4- substituted sulfamoylphenyl] aminoacridine-4-carboxamide] phenylenediamine. The third and fourth are 1-[4-substituted sulfamoylphenyl] aminoacridine-4-carboxylic acid [4-substituted sulfamoylphenyl] amide. The fifth and sixth are 9-ox-1-[4-substituted amino sulfamoylphenyl]-9-10- dihydroacridine-4-carboxylic acid [4- substituted sulfamoylphenyl] amide. The seventh is 2-substituted phenyl-2,6-dihydropyrazolo [3,4,5-kl] acridine-5-carboxylic acid [4- substituted sulfamoylphenyl] amide. The eighth is 4-[5-[N'- phenylhydrazinocarbonyl-6H-pyrazolo [3,4,5-kl acridine-2-yl]-N- substituted benzene sulfonamide. The last one belongs to 2- substituted phenyl-2,6-dihydropyrazolo [3,4,5-kl] acridine-5-carboxyli acid [4-substituted sulfamoylphenyl] hydrazide

Synthesis, molecular modeling and anticancer activity of certain acridine derivatives

Eight series of new acridine derivatives of anticipated antitumor activity were synthesized. The first and second series belong to 9- anilinoacridines. The third series belongs to 9-anilinoacridine-4- ylmethylamino benzenesulfonamides. The fourth one composes of acridone methylamino benzenesulfonamides. The fifth and sixth series comprise of 9-anilinoacridine-4-acetamide derivatives. The seventh series is the derivatives of 9-oxo-9,10-dihydroacridine-4-acetamide. The last series includes 9-oxo-9,10-dihydroacridine-2-sulfonamides. Also, one known final compound has been synthesized following a new pathway. The rationale behind the synthesis of these compounds, their methods of synthesis as well as their antitumor activity, were discussed