A new 3, 4-epoxyfurocoumarin from Heracleum moellendorffii Roots

Activity-guided isolation of Heracleum moellendorffii roots led to four coumarin derivatives as acetylcholinesterase inhibitors. The structures of these isolates were characterized by spectroscopic method to be angelicin (1), isobergapten (2), pimpinellin (3), and (3S, 4R)-3, 4-epoxypimpinellin (4). All the isolated compounds 1, 2, 3, and 4 showed moderate inhibition activities against acetylcholinesterase with the IC₅₀ values of 10.2, 18.1, 21.5 and 22.9 µM, respectively. (3S, 4R)-3, 4-Epoxypimpinellin (4) was newly isolated from the plant source.

A Case of Fibrous Dysplasia Involving the Nasal Septum

Fibrous dysplasia is a developmental disease of bone in which the normal substance of the interior of the bone is replaced by fibro-osseous connective tissue. It exhibits varying degrees of osseous metaplasia histologically. Craniofacial fibrous dysplasia frequently affects the maxilla, frontal bone, and mandible. The nasal septum is rarely affected. There is only one reported case of fibrous dysplasia arising in the septum internationally. Hence, we report a case of fibrous dysplasia of the nasal septum with a review of literature.

A Case of Multiple Bony Dehiscences of Semicircular Canals and Vestibule Presenting as Dizziness and Hearing Loss / 대한이비인후과학회지

Dehiscence of the bone overlying the semicircular canals has been shown to have effects on vestibular and auditory function. This case report presents a 48-year-old man presenting atypical vestibular manifestations and bilateral hearing loss. His temporal bone CT scans demonstrated bony dehiscence of posterior semicircular canal and vestibule in the right, superior and posterior semicircular canals in the left.

A Case of Pulsatile Tinnitus by Sigmoid Sinus Diverticulum / 대한이비인후과학회지

The pulsatile tinnitus is characterized by a rhythmic sound that is synchronous with the patient's heart beat. Accurate diagnosis is imperative, because in many patients, a treatable underlying etiology can be identified. Sigmoid sinus diverticulum is known to be one of the treatable causes of venous pulsatile tinnitus, but rarely reported in the literature. We experienced a case of sigmoid sinus diverticulum in a 58-year-old female presenting a pulsatile tinnitus. So we report this case with a review of literature.

A Case of Huge Nasopalatine Duct Cyst With Infection / 대한이비인후과학회지

Nasopalatine duct cysts are the most common nonodontogenic developmental cyst originating in the incisive canal of maxilla and occuring in approximately 1% of the population. Clinical presentation is asymptomatic in small cysts, but shows swelling, pain and drainage from the hard palate in large cysts. The definite diagnosis should be based on clinical, radiological and histopathologic findings. The treatment of nasopalatine duct cysts consists of an enucleation of the cystic tissue, only in rare cases a marsupialization needs to be performed. We report a case of infected nasopalatine duct cyst in a 65-year-old man. He complained of painful swelling in the midline and nasolabial area. Physical examination revealed a huge tender mass in the midline of upper jaw. Diagnosis was suggested on the basis of computed tomography. Under the general anethesia, an enucleation was performed via sublabial approach.