1.
Indian J Physiol Pharmacol
;
1980 Oct-Dec; 24(4): 346-50
Artigo
em Inglês
| IMSEAR
| ID: sea-107030
RESUMO
Insulin (5 to 40 I.U.) produced dose-dependent positive inotropic effect in the isolated rat heart. The responses to insulin were markedly inhibited in the presence of propranolol (1 . 1X10(-6) M). Insulin responses were markedly reduced in reserpine pretreated (5 mg/kg, i.p.) rats. Theophylline (4.4 mM), the phosphodiesterase inhibitor, potentiated the responses to insulin, whereas imidazole (20 mM), the phosphodiesterase stimulator inhibited the responses to insulin. The data suggest that the positive inotropic effects of insulin in rat heart is mediated through the release of cardiac catecholamines which stimulates beta-adrenoceptors. The final mediator of cardiac action seems to be cyclic-AMP.
Assuntos
Animais , Interações Medicamentosas , Feminino , Imidazóis/farmacologia , Insulina/farmacologia , Masculino , Contração Miocárdica/efeitos dos fármacos , Propranolol/farmacologia , Ratos , Estimulação Química , Teofilina/farmacologia
2.
Artigo
em Inglês
| IMSEAR
| ID: sea-22911
3.
J Indian Med Assoc
;
1973 Feb; 60(3): 83-6
Artigo
em Inglês
| IMSEAR
| ID: sea-96740
4.
Indian J Pediatr
;
1967 Dec; 34(239): 437-9
Artigo
em Inglês
| IMSEAR
| ID: sea-79954