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Objective To study the relationship between thyroid hormone level and 24h urine protein quanti-tation in patients with severe preeclampsia. Methods From August 2015 to October 2017,180 patients with severe preeclampsia who were treated in the Third People's Hospital of Qingdao were selected. The level of thyroid-stimula-ting hormone ( TSH) was detected by chemiluminescence particles immune method. According to the test results,the patients were divided into normal group (n=110,TSH=0. 3-3. 3mU/L) and hypothyroidism group (n=70,TSH>3. 3mU/L). Another 240 healthy pregnant women who admitted in the Third People's Hospital of Qingdao during the same period were selected as control group. The TSH,free triiodothyronine (FT3),free thyroxine (FT4) levels and 24h urine protein quantitation were compared among the three groups. The correlation between the level of thyroid hormone and 24h urine protein quantitation,the results of thyroid autoantibody in patients with severe preeclampsia were analyzed.Results The FT4,FT3 levels in the normal group were (11.92±2.54)pmol/L,(5.22 ±1.25)pmol/L, respectively,which in the hypothyroidism group were (9. 02 ± 1. 09) pmol/L,(3. 92 ± 1. 57) pmol/L,respectively, which were all lower than those in the control group (t=6. 657,16. 758,13. 221,18. 245,all P<0. 05),which in the hypothyroidism group were lower than those in the normal group (t=9. 031,6. 149,all P<0. 05). The TSH,24h urine protein quantitation levels in the normal group were (2. 56 ± 0. 86) mU/L,(66. 51 ± 18. 52) mg,respectively, which in the hypothyroidism group were (5. 87 ± 3. 02) mU/L,(79. 14 ± 12. 58) mg,respectively,which were all higher than those in the control group(t=2. 330,7. 197,16. 417,13. 335,all P<0. 05),which in the hypothyroidism group were higher than those in the normal group (t=10. 883,5. 014,all P<0. 05). There was positive correlation between serum TSH and 24h urine protein quantitation in patients with severe preeclampsia (r=0. 254,P=0. 001). There was negative correlation between FT4 and 24h urine protein quantitation (r= -0. 182,P=0. 025). There was no correlation between serum FT3 and 24h urine protein quantitation (r= -0. 080,P=0. 330). The positive rates of TPO Ab,TG Ab were 12. 86％,18. 57％ in hypothyroidism group,there were no statistically significant differences compared with 10. 91％,14. 55％ in the normal group (χ2 =0. 158,0. 513;P=0. 691,0. 474). Conclusion There is correlation between thyroid hormone levels and 24h urine protein quantitation in patients with severe preeclampsia. It has great significance for clinical treatment of severe preeclampsia by detecting the level of thyroid hormone.
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Objective To analyze the antibiotic phenotype of Pseudomonas aeruginosas that were isolated from pleural samples in our hosptial and test relative genes that may cause antibiotic resistance in order to provide information for clinical treatment . Methods BioMerieux Bact/ALERT 3D 120 blood culture system was used to culture pleural samples .Simens MicroScan Walk‐Away 96 was employed for bacterial identification and susceptibility test .Imipenem‐EDTA double disk method was used for screen‐ing MBL‐producing isolates .PCR was used for testing OprD ,VIM and IMP .Results 14 of 38 Pseudomonas aeruginosas isolates showed resistance to Imipenem and 2 were with multi‐resistance .4 isolates produced MBL .Only two were found lack of OprD gene among the 14 isolates ,and IMP and VIM genes were detected in 2 isolates .Conclusion The Pseudomonas aeruginosas from pleural infection show relative higher resistant rate to Imipenem ,and the exsiting mechanisms of Imipenem resistance included MBL (VIM and IM P genes) and lack of OprD .
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Objective To analyze the significance of urinary type Ⅰ collagen cross-linked N-telopeptides (uNTX) for the prognosis and response to therapy of bone metastatic neoplasms.Methods The subjects were divided into 3 groups: A,B and C.The levels of uNTX were measured by enzymatic immunoassay kit,and the activity of serum alkaline phosphatases(AKP) and calcium concentration were measured simultanuously.Results uNTX levels positively correlated with bone metastatic neoplasms,and were markedly high in the patients with extensive bone collagen breakdown.Conclusions uNTX is more sensitive than the activity of serum AKP and plasma calcium concentration for bone metastasis of neoplasms,so it is significant in differentiating and monitoring bone metastatic neoplasms.The measurement of uNTX is an early objective methods for evaluation of prognostic response to therapy of bone metastatic neoplasms.