RESUMO
The strawberries [Fragaria x ananassa] of Rosaceae family are an accomplished source of bioactive compounds such as ascorbic acid and diverse range of polyphenols including anthocyanins, phenolic acids, flavonols, ellagitannins etc. These phenolic compounds classify strawberry as an important health promoting food. Strawberries are proved to have potent antioxidant capacity in various in vitro assay systems. The in vivo beneficial effects are getting explored against various ailments including cancer, metabolic syndrome, and cardiovascular diseases. The present research study was designed to analyze the effect of strawberry fruit extracts [water and methanol] against alloxan induced hyperglycemia in albino rats of Wister strain. Upon alloxan [150mg/kg body weight] induction, the diabetic animals showed marked increase in the values of plasma glucose, urea, uric acid, creatinine and concomitant decrease in body weight and plasma insulin level. The oral administration of strawberry extracts for 45 days in diabetic animals reversed the biochemical changes significantly [P[private use character]0.05] to near normal. Furthermore, the restoration of body weight loss was also observed. The results suggest that the strawberry extract has effective hypoglycemic activity against alloxan diabetes. The poly phenolic antioxidant contents of the strawberry fruit extracts are responsible for the observed biological effect
RESUMO
Strawberries contain antioxidant phytochemicals, which have been shown to beneficial against inflammation, cardiovascular disease, cancer, obesity, neurodegeneration, hyperglycaemia and associated diabetic complications. Freeze-dried strawberry powder [FSP] is effective in controlling metabolic syndrome and cardiovascular risk factors. The present investigation was designed to evaluate the effect of FSP on alloxan-induced diabetes in rats. Diabetes was induced in male Wistar albino rats by intraperitoneal injection of alloxan monohydrate [150 mg/kg bw], and treatment with FSP [700 mg/day for 45 days] was started 48 h after alloxan injection. Blood glucose, insulin, C-peptide, haemoglobin, renal function markers [urea, uric acid and creatinine] and enzyme markers [aspartate and alanine transaminases and alkaline phosphatase] were assayed with suitable methods. Animals given alloxan had significant body weight loss, poor glucose tolerance and increased blood glucose with concomitant decreases in insulin, C-peptide and haemoglobin values, and significant [p < 0.05] changes in the levels of renal function markers and enzyme activities. Oral administration of FSP for 45 days significantly [p < 0.05] reverted the body weight loss, hyperglycaemia, biochemical parameters, enzyme activities and insulin levels to near normal levels. FSP can revert alloxan-induced diabetes and its complications. The antioxidant properties of the fruit probably play a major role in the observed changes
Assuntos
Animais de Laboratório , Pós , Complicações do Diabetes , Aloxano , Diabetes Mellitus Experimental , Ratos WistarRESUMO
Fishery waste and by-products are valuable sources of raw material for recovery of antioxidant and bioactive 3tides
Due to the increased demand for protein hydrolysates with antioxidative properties by various sectors of nsumable food, health care and pharmaceutical industries, the present study focused in the production of fish protein olysate [FPH] by enzymatic digestion from the backbone of Rastrelliger kanagurta [Indian mackerel] and evaluated | antioxidant potential
The observed results of the degree of hydrolysis suggest that the rapid phase of proteolytic savage was occurred in the first 60 minutes of incubation and during this period, the rate of hydrolysis was found to be with increasing ratio of enzyme to substrate concentration
The result of the antioxidant properties clearly tficates that thel, 1- diphenyl-2 picrylhydrazyl [DPPH] radical scavenging efficacy of FPH was similar to that of Jtic antioxidants like butylated hydroxyl toluene [BHT]
The FPH also exhibited significant reducing power ability I great potential to inhibit lipid peroxidation in equivalence with that of synthetic and natural antioxidants such as fand a-tocopherol respectively
The overall findings of the study reveal that, FPH produced by tryptic digestion has able amount of bioactive peptides with potent antioxidant properties
The synthesized FPH is a good candidate irfurther development into a commercial food additive