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1.
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 609-611, 2003.
Artigo em Chinês | WPRIM | ID: wpr-240908

RESUMO

<p><b>OBJECTIVE</b>To observe the effect of Pingchuan Mixture (PCM) on plasma eosinophil cation protein (ECP), interleukin-5 in bronchial alveolar lavage fluid (BALF) and inflammatory cell count in experimental guinea pigs with asthma.</p><p><b>METHODS</b>The eosinophil, neutrophil, lymphocyte count were conducted by conventional method, IL-5 was detected by ELISA and ECP determined by RIA.</p><p><b>RESULTS</b>Levels of eosinophil, neutrophil, lymphocyte, ECP and IL-5 after treatment were significantly lower than those before treatment, the difference between groups treated respectively by PCM, aminophylline, dexamethasone and Dingchuan Zhike Tablet was insignificant.</p><p><b>CONCLUSION</b>PCM could treat asthma by reducing the inflammatory cell count, ECP and IL-5.</p>


Assuntos
Animais , Asma , Metabolismo , Proteínas Sanguíneas , Metabolismo , Líquido da Lavagem Broncoalveolar , Química , Medicamentos de Ervas Chinesas , Farmacologia , Proteínas Granulares de Eosinófilos , Eosinófilos , Metabolismo , Cobaias , Interleucina-5 , Metabolismo , Ovalbumina , Ribonucleases , Metabolismo
2.
China Journal of Chinese Materia Medica ; (24): 139-143, 2002.
Artigo em Chinês | WPRIM | ID: wpr-274993

RESUMO

<p><b>OBJECTIVE</b>To explore the effects of Zhikuofang, a TCM prescription, and Ofloxacin on the inflammation and cytostatics of the airway model of bronchiectasis.</p><p><b>METHOD</b>The airway model of bronchiectasis (AMB) was set up and infused with Ps. Aeruginosa. A comparison between the effects of Zhikuofang and Of loxacin on the AMB was made.</p><p><b>RESULT</b>Zhikuofang is better than Ofloxacin in following aspects: lowering the density of inflammation cells in blood, decreasing the volume of tracheal secretion and inhibiting the cytostatics (IL-8 and TNF-alpha) of the trachea tissue, but Ofloxacin is more effective in diminishing the amount of bacteria in trachea flushing liquor. There was no marked difference between them in their histopathy effects on the trachea.</p><p><b>CONCLUSION</b>Zhikuofang probably plays antiphlogistic and bacteriostatic effects by inhibiting the IL-8 and TNF-alpha, resisting secretion, decreasing the inflammation cells and resisting inflammation of trachea.</p>


Assuntos
Animais , Feminino , Masculino , Ratos , Anti-Infecciosos , Farmacologia , Bronquiectasia , Metabolismo , Microbiologia , Bronquite , Metabolismo , Microbiologia , Combinação de Medicamentos , Medicamentos de Ervas Chinesas , Farmacologia , Interleucina-8 , Metabolismo , Ofloxacino , Farmacologia , Fitoterapia , Plantas Medicinais , Química , Infecções por Pseudomonas , Ratos Sprague-Dawley , Fator de Necrose Tumoral alfa , Metabolismo
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