RESUMO
Contrast-induced acute kidney injury (CI-AKI) is a frequent challenge following the injection of contrast media and its subsequent oxidative stress. The aim of the present study was to evaluate the preventive effects of coenzyme Q10 (Q10), as a mitochondrial-targeted antioxidant in CI-AKI in diabetic patients, who account for a large proportion of angiographic cases. A total of 118 diabetic patients were randomly assigned to receive 120 mg of oral coenzyme Q10 (Q10 group) or placebo (Placebo group) for four days, starting 24 hours before contrast media injection. Blood urea nitrogen (BUN), serum and urinary creatinine, estimated glomerular filtration rate (eGFR), urinary malondialdehyde (UMDA), urinary total antioxidant capacity (UTAC), and urinary mitochondrial to nuclearDNA ratios (mtDNADNA ratio) were evaluated before and after the treatment period. Urine sediments were also evaluated to report the urine microscopy score (UMS).The levels of BUN, serum and urine creatinine, and UMS were similar in the Q10 and placebo groups. EGFR was lower in the Q10 group before the treatment (p=0.013) but not after. The urinary mtDNADNA ratio was 3.05±1.68 and 3.69±2.58 in placebo and Q10 groups, but UTAC was found to be lower in Q10 both before (p=0.006) and after the treatment (p＜0.001). The incidence of CI-AKI was 14.40% and the mtDNANDA ratio was similar between CI-AKI and non-CI-AKI patients. In conclusion, Q10 treatment shows no favorable effect on prevention of CI-AKI or a urinary mtDNADNA ratio among diabetic patients.
RESUMO
Objectives@#This study aims to evaluate the effect of a mixture of fennel and valerian extracts on hot flashes and sleep disorders of postmenopausal women in Iran. A randomized trial was conducted. @*Methods@#A total of 76 postmenopausal women were randomly assigned to either of the two groups: fennel-valerian extract or control.One 500 mg fennel-valerian extract capsule was given twice, daily for 8 weeks. The 500 mg oral placebo capsule (starch) was given the same way. @*Results@#The mean duration of hot flashes increased in both the groups over time (P < 0.001). The mean frequency and severity of hot flashes in the intervention group were significantly lower than in the control group, in the first and second months after intervention (P < 0.050). Women in the fennel-valerian extract group had a significantly lower Pittsburgh Sleep Quality Index score than the control group 2 months after intervention (P = 0.030). @*Conclusions@#This study found that fennel-valerian extract was effective for relieving sleep disorders as well as the severity and frequency of hot flashes compared with a placebo.
RESUMO
Achillea tenuifolia Lam [Asteraceae] afforded a methanolic extract from which after fractionation in solvents with different polarities two known flavones 3', 5- dihydroxy- 4', 6, 7- trimethoxy flavone [eupatorine, compound 3], 5- hydroxy- 3', 4', 6, 7- tetramethoxyflavone [compound 4], besides stearic acid [compound 1 ], lupeol [compound 2], daucosterol [beta- sitosterol 3-O- beta- D- glucopyranoside, compound 5], 2, 4- dihydroxy methyl benzoate [compound 6] were isolated for the first time. The structure of isolated compounds was elucidated by means of different spectroscopic methods such as UV, IR, Mass and [1]H- NMR [1D and 2D] and [13]C-NMR. For further confirming of structures of isolated compounds, comparison of the spectral data of them with those reported in the litratures have been done
RESUMO
Achillea tenuifolia Lam. [Asteraceae] afforded a dichloromethane fraction from which three known compounds beta-sitosterol [compound1], 5-hydroxy, 4',6,7- trimethoxy flavone [salvigenin compound 2], and methyl-gallate [compound 3] were isolated for the first time. The structure of isolated compounds was elucidated by different spectroscopic methods. Applying the molar-ratio method, the complexation of salvigenin with Fe [III], Cu[II] and Zn[II], the most abundant type of metal ions in the body, were then evaluated. It was determined that stoichiometric ratio of salvigenin with these cations were as Fe[Salvigenin][2] [H2O][2] and Cu[Salvigenin][2][H2O][2] in methanolic solution without pH control, while zinc ions didn't form significant complexes. The results were confirmed more, by computational molecular modeling of the structure of proposed ligand-complexes by semi-imperical PM3 calculations, which determined negative heat of formation for the complexes Fe[III] and Cu[II] ions as -689.7 and -573.5, respectively and proposed chelating affinity of salvigenin in the following order: Fe[III] > Cu[II] >> Zn[II]