Correlation between chronic periodontitis and pulmonary ventilation function / 中国基层医药

Objective:To investigate the correlation between chronic periodontitis and pulmonary ventilation function.Methods:A total of 135 patients with chronic periodontitis who received treatment in Yuyao People's Hospital of Zhejiang Province between June 2014 and December 2019 were included in this study. They were divided into group A (stage I, initial lesion, n = 45), group B (stage II, early lesion, n = 45), group C (stage III, confirmed lesion, n = 45) according to the severity of periodontal lesion. Lung ventilation function indexes and serum levels of interleukin-6 (IL-6), IL-8 and tumor necrosis factor-alpha (TNF-α) were compared among the three groups. The correlation between periodontal condition and lung ventilation function indexes was analyzed. Results:Probing depth (PD), clinical attachment loss (CAL), number of missing teeth, alveolar bone resorption level were (1.67 ± 0.65) mm, (2.48 ± 0.44) mm, 0 pieces, and (1.38 ± 0.23) mm in group A, (2.05 ± 0.30) mm, (4.04 ± 0.97) mm, 1 piece, (3.37± 0.73) mm in group B, and (2.23 ± 0.47) mm, (5.17 ± 0.75) mm, 3 pieces, (6.48 ± 0.62) mm in group C. With the worsening of the disease, PD, CAL, number of missing teeth, and alveolar bone resorption level were gradually increased. PD, CAL and alveolar bone resorption level in group C were significantly higher than those in group A ( t = 4.68, 20.75, 51.74, all P < 0.001) and group B ( t = 2.17, 6.18, 21.78, P = 0.033, < 0.001, < 0.001). PD, CAL and alveolar bone resorption level in group B were significantly higher than those in group A ( t = 3.56, 9.82, 17.44, all P < 0.001). There was no significant difference in the number of missing teeth ( P > 0.05). Serum IL-6, IL-8 and TNF-α levels were (11.28 ± 4.26) ng/L, (7.48 ± 1.97) ng/L, (14.59 ± 2.11) ng/L in group A, (17.09 ± 4.91) ng/L, (10.82 ± 2.10) ng/L, (19.95 ± 4.48) ng/L in group B, and (26.47 ± 5.86) ng/L, (15.06 ± 2.75) ng/L, (33.76 ± 6.30) ng/L] in group C. With the worsening of the disease, serum IL-6, IL-8 and TNF-α levels were gradually increased. Serum IL-6, IL-8 and TNF-α levels in group C were significantly higher than those in group A ( t = 14.06, 15.03, 19.36, P < 0.001) and group B ( t = 8.23, 8.22, 11.98, all P < 0.001). Serum IL-6, IL-8 and TNF-α levels in group B were significantly higher than those in group A ( t = 6.00, 7.78, 7.26, P < 0.001). The percentage of the maximum expiratory volume in the first second to the predicted value (FEV 1%pre) and the ratio of the maximum expiratory volume in the first second to the forced vital capacity (FEV 1/FVC) were (81.53 ± 6.30)% and (68.73 ± 4.65)% in group A, (70.47 ± 5.25)% and (60.86 ± 3.42)% in group B, and (59.02 ± 3.41)% and (56.93 ± 4.21)% in group C. With the worsening of the disease, FEV 1%pre and FEV 1/FVC were gradually decreased. FEV 1%pre and FEV 1/FVC in group C were significantly lower than those in group A ( t = 21.08, 12.62, both P < 0.001) and group B ( t = 12.27, 4.86, both P < 0.001). FEV 1%pre and FEV 1/FVC in group B were significantly lower than those in group A ( t = 9.05, 9.25, both P < 0.001). Spearman correlation analysis showed that serum IL-6, IL-8 and TNF-α levels were negatively correlated with FEV1%pre and FEV 1/FVC ( r = -0.50, -0.28, -0.42, -0.61, -0.34, -0.51, all P < 0.05). Conclusion:There is a correlation between chronic periodontitis and pulmonary ventilation function. Inflammatory mediators may be involved in chronic periodontitis as internal systemic factors.

Current status of professional identity among undergraduates majoring in public affairs management and the related influencing factors / 中华医学教育探索杂志

Objective@#To investigate the current status of professional identity among the undergraduates majoring in public affairs management and the related influence factors.@*Methods@#A stratified cluster sampling method was used to conduct a questionnaire survey among the 115 undergraduates majoring in public affairs management in a medical university in Harbin, China, and the contents of the questionnaires included general status and professional identity. The t-test, one-way analysis of variance, and multiple linear regression analysis were used to analyze the influencing factors of professional identity. In-depth interviews were conducted for some students to explore the profound influencing factors for professional identity among the students majoring in public affairs management.@*Results@#The overall level of professional identity was low among the undergraduates majoring in public affairs management in the medical university in Harbin, and the score of professional identity was 3.25±0.56. The scores of cognitive dimension, emotional dimension, behavioral dimension, and applicable dimension were 3.41±0.69, 3.21±0.78, 3.24±0.71, and 3.13±0.72, respectively. The multivariate analysis showed that grade, academic performance, major selection, and children number in family had significant influence on their professional identity. The students who were at grade four, who had high academic record (b=-0.276, P<0.01), who chose this major independently (b=-0.277, P<0.01), and who were the only child (b=-0.233, P<0.05) had a high score of professional identity. As for the undergraduates at different grades, the undergraduates at grades two and three had a significantly lower score of professional identity than those at grade four (b=-0.296 and -0.369, P<0.05), while there was no significant difference between the undergraduates at grades one and four (b=-0.008, P>0.05). Furthermore, the students with a high score of professional identity had higher possibility to pursue the job related to this major than those with a low score (3.39±0.53 vs. 2.92±0.49, t=4.414, P<0.01).@*Conclusion@#Universities should strengthen the publicity of the major of public affairs management, optimize the curriculum, and add job experience, so as to enhance professional identity among students with this major and provide talent for the field of public health management.

Current status of professional identity among undergraduates majoring in public affairs management and the related influencing factors / 中华医学教育探索杂志

Objective To investigate the current status of professional identity among the undergraduates majoring in public affairs management and the related influence factors.Methods A stratified cluster sampling method was used to conduct a questionnaire survey among the 115 undergraduates majoring in public affairs management in a medical university in Harbin,China,and the contents of the questionnaires included general status and professional identity.The t-test,one-way analysis of variance,and multiple linear regression analysis were used to analyze the influencing factors of professional identity.In-depth interviews were conducted for some students to explore the profound influencing factors for professional identity among the students majoring in public affairs management.Results The overall level of professional identity was low among the undergraduates majoring in public affairs management in the medical university in Harbin,and the score of professional identity was 3.25 ± 0.56.The scores of cognitive dimension,emotional dimension,behavioral dimension,and applicable dimension were 3.41 ± 0.69,3.21 ± 0.78,3.24 ± 0.71,and 3.13 ± 0.72,respectively.The multivariate analysis showed that grade,academic performance,major selection,and children number in family had significant influence on their professional identity.The students who were at grade four,who had high academic record (b =-0.276,P＜ 0.01),who chose this major independently (b=-0.277,P＜0.01),and who were the only child (b=-0.233,P＜ 0.05) had a high score of professional identity.As for the undergraduates at different grades,the undergraduates at grades two and three had a significantly lower score of professional identity than those at grade four (b=-0.296 and-0.369,P＜0.05),while there was no significant difference between the undergraduates at grades one and four (b=-0.008,P＞0.05).Furthermore,the students with a high score of professional identity had higher possibility to pursue the job related to this major than those with a low score (3.39 ± 0.53 vs.2.92 ± 0.49,t=4.414,P＜0.01).Conclusion Universities should strengthen the publicity of the major of public affairs management,optimize the curriculum,and add job experience,so as to enhance professional identity among students with this major and provide talent for the field of public health management.

Effect of phosphorus deficiency on erythrocytic morphology and function in cows

The aim of this study was to evaluate the influence of phosphorus (P) deficiency on the morphological and functional characteristics of erythrocytes in cows. Forty Holstein-Friesian dairy cows in mid-lactation were randomly divided into two groups of 20 each and were fed either a low-P diet (0.03% P/kg dry matter [DM]) or a control diet (0.36% P/kg DM). Red blood cell (RBC) indices results showed RBC and mean corpuscular hemoglobin decreased while mean corpuscular volume increased significantly (p < 0.05) in P-deficient cows. Erythrocyte morphology showed erythrocyte destruction in P-deficient cows. Erythrocytes' functional characteristics results showed total bilirubin and indirect bilirubin concentrations and aspartate transaminase and alanine transaminase activity levels in the serum of P-deficient cows were significantly higher than those in control diet-fed cows. Activities of superoxide dismutase and glutathione peroxidase in erythrocytes were lower, while the malondialdehyde content was greater, in P-deficient cows than in control diet-fed cows. Na⁺/K⁺-ATPase and Mg²⁺-ATPase activities were lower in P-deficient cows than in control diet-fed cows; however, Ca²⁺-ATPase activity was not significantly different. The phospholipid composition of the erythrocyte membrane changed and membrane fluidity rigidified in P-deficient cows. The results indicate that P deficiency might impair erythrocyte integrity and functional characteristics in cows.

Systematic Review of Acupuncture-moxibustion for Deglutition Disorders after Cerebral Stroke / 上海针灸杂志

Objective To evaluate the clinical efficacy of acupuncture-moxibustion in treating deglutition disorders after cerebral stroke.Method By computer and manual literature retrieval, eligible randomized controlled trials (RCTs) were collected for systematic review by using the Cochrane method, and the meta analysis was performed by using Revman 5.2.Result Nine studies were recruited, covering 577 subjects of deglutition disorders due to cerebral stroke. The total effective rate of the treatment group was significantly higher than that of the control group [RR=0.36, 95%CI (0.25,0.50), Z=5.80 (P<0.00001)]. The treatment group was superior to the control group in improving the water drinking test (χ2=108.73,P<0.00001).Conclusion Acupuncture can produce a content therapeutic efficacy in treating deglutition disorders due to cerebral stroke, which still requires high-quality large-sample-size clinical RCTs for further verification.

Effect of Different Needle-retaining Lengths on the Therapeutic Efficacy of Acupuncture in Treating Post-stroke Shoulder Pain / 上海针灸杂志

ObjectiveTo observe the effect of different needle-retaining lengths on the clinical efficacy of acupuncture in treating post-stroke shoulder pain.MethodSixty patients were randomized into a 30 min group and a 60 min group, 30 cases in each group. The same acupuncture treatment protocol was adopted in the two groups, and the acupuncture treatment was given once a day, 5 sessions a week, for 20 times in total. The Visual Analogue Scale (VAS), shoulder pain frequency, and Fugl-Meyer Assessment (FMA) were observed before treatment and after 4-week treatment.ResultThe scores of each index were significantly improved in both groups after treatment (P<0.01), and there were significant differences in comparing each index score between the two groups after treatment (P<0.05,P<0.01).ConclusionIn the treatment of post-stroke shoulder pain with acupuncture, 30 min needle-retaining is better than 60 min in comparing the analgesic effect.

Effect of Different Needle-retaining time on Post-stroke Hypermyotonia in Acupuncture Treatment / 上海针灸杂志

Objective To compare the effect of different needle-retaining time on post-stroke hypermyotonia in acupuncture treatment.Method Ninety patients with post-stoke hypermyotonia were randomized into group A, group B, and group C, 30 in each group. The three groups were all treated by the twelve hand-foot needling method from the thirteen therapies invented by acupuncture master WANG Le-ting, once a day, 5 times a week, 20 times in total. For group A, needles were removed right after needling qi arrived; for group B, needles were retained for 30 min after needling qi arrived; for group C, needles were retained for 60 min after needling qi arrived. The modified Ashworth Scale (MAS), Clinical Spasticity Index (CSI), and Fugl-Meyer assessment scale (FAS) were adopted for observation before and after intervention.Result After treatment, the MAS was significantly changed in all three groups (P<0.05). The CSI score and FAS score of the affected limb were significantly changed in all three groups after intervention (P<0.05). Both group A and B were significantly different from group C in comparing the CSI and FAS scores (P<0.05).Conclusion Compared to retaining needles for 60 min, acupuncture without retaining needles or retaining needles for 30 min can produce better effect in improving post-stroke hypermyotonia, spasticity, and motions of limbs.

An Epidemiologic Study of Hearing Impairment of children under 14 Years Old in Guizhou Province / 听力学及言语疾病杂志

Objective To undertake a survey on the prevalence, pathogenic factors and treatment needs of hearing impairment in children under 14 years old in Guizhou province. Methods Using the probability proportion to size (PPS) method, 2 068 children aged 0～14 years were included in the study and in 30 clusters in Guizhou province based on the WHO protocol. Results For children aged 0～14 years, the prevalence of hearing impairment was 3.48% and the prevalence of hearing disability was 1.84 %. There were statistically differences of the prevalence of hearing disability between children aged 7～ 14 years (2.66 %) and 0～ 6 years (0. 51%), and the differences also in hearing impairment between male children (4.22%) and female children (2.54%). The main causes of hearing impairment were ear diseases (50.00%), non-infective conditions (11.11%), genetic conditions (20.83 %) and unknown causes (27. 77%). 3. 58% of all subjects needed medical or surgical treatment and 2. 32% needed hearing aids. Conolusion The prevalence of hearing disability of children under 14 years old in Guizhou province was higher than that of other cities. The main cause of the hearing impairment of children was otitis media with hereditary deafness also ranked in top.

Effect of disequilibrium of calcium homeostasis on apoptosis of MDCC MSB1 cells induced by lanthanum chloride / 中国兽医学报

To investigate the effect of the disequilibrium of calcium homeostasis on the apoptosis of MDCC-MSB1 cells induced by lanthanum chloride(LaCl3 ), MDCC-MSB1 cells was conventionally cultured in RPMI1640, which was tured for 24 h, MTT was utilized to detect the cell multiplication inhibition ratio,DNA ladder and TUNEL to detect apoptosis,the Fura-2/AM as the probe to detect the [Ca2+]i within cells. The results indicated when LaCl3 concen and [Ca2+]i also increased,and presented a dose-effectiveness relationship. LaCl3 could restrain the proliferation of MDCC-MSB1 cells,suggesting their apoptosis induced by changing [Ca2+]i.

Report on the study of who ear and hearing disorders survey protocol in Guizhou province / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To undertake a population-based survey on the prevalence, pathogenic factors and medical requirements of ear and hearing impairment.@*METHOD@#Using the probability proportion to size (PPS) method, 6626 residents were investigated in 30 clusters with the WHO protocol.@*RESULT@#The prevalence of hearing impairment was 17.1% (the standardized rate: 17.6% in the whole country). Degrees of hearing impairment were mild (11.0%), moderate (4.2%), severe (1.4%), and profound (0.5%). Among them, male were 663(20.2%) and female were 468 (14.0%). The prevalence of hearing disability was 6.1% (the standardized rate: 6.5% in the whole country). The causes of hearing impairment were ear disorders (31.4%), non-infectious (42. 5%), genetic condino (6.7%), infectious disease (0.4%) and undetermined cause (29.3%). 13.8% of person needed otology and/or audiology actions. 9.1% of person needed hearing aid.@*CONCLUSION@#The prevalence of hearing impairment and hearing disability is higher than last twenty years and it can provide scientific data for drawing up precaution and control strategies on deafness for government.

Simultaneous determination of three alkaloids in different years and parts of Sophora flavescens by HPLC / 中成药

AIM: To establish an HPLC method for determining sophocarpine,sophoridine and oxymatrine in Sophora flavescens Ait,so as to investigate their contents in different years and different parts. METHODS: An Elite Hypersil NH2 column(250 mm ? 4. 6 mm,5 ?m) was used with the mobile phase being acetonitrile-absolute alcohol-3% phosphoric acid solution(82 ∶ 10 ∶ 8),flow rate being 1 mL/min,determinating wavelength being 220 nm,the column temperature being 26 ℃,The injection volume was 5 ?L. RESULTS: The calibration curves of sophocarpine,sophoridine and oxymatrine were in good linearity over the ranges of 0. 004 99 - 0. 149 7 ?g(r = 0. 999 9),0. 025 08 - 0. 752 25 ?g(r = 0. 999 9),0. 075 38 - 2. 261 25 ?g(r = 0. 999 9); and the average recovery of sophocarpine,sophoridine and oxymatrine was 99. 91% ,99. 26% ,100. 27% with RSD of 1. 11% , 0. 82% ,2. 18% respectively. CONCLUSION: The HPLC method shows a good separation,reproducibility and accuracy,there are obvious differences in the contents of three alkaloids in different years and different parts of Sophora flavescens Ait. The results provide important data for quality evaluation and utilization of Sophora flavescens materials.