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Artigo em Chinês | WPRIM | ID: wpr-252736

RESUMO

<p><b>AIM</b>To study the effect of angiotensin-(1-7) on the kidney of diabetic rats by observing the mRNA expression of PDGF and TGF-beta1.</p><p><b>METHODS</b>SD rats were divided into three groups: Group C (uni-nephrectomy control group), Group D (diabetic model control group), Group T (Ang-(1-7) treated group). We evaluated blood glucose,urea nitrogen, creatinine and urine albumin excretion respectively, studied the renal morphology by light microscope, and detected the gene expression of PDGF, TGF-beta1 in renal tissue by RT-PCR technique.</p><p><b>RESULTS</b>There was significant difference between the group D and T about the RW/BW, renal morphology, the total urine protein and the mRNA expression of PDGF and TGF-beta1.</p><p><b>CONCLUSION</b>Ang-(1-7) can relieve the renal process of diabetic rats.</p>


Assuntos
Animais , Masculino , Ratos , Angiotensina I , Farmacologia , Diabetes Mellitus Experimental , Metabolismo , Nefropatias Diabéticas , Metabolismo , Rim , Metabolismo , Patologia , Fragmentos de Peptídeos , Farmacologia , Fator de Crescimento Derivado de Plaquetas , Genética , Metabolismo , RNA Mensageiro , Genética , Metabolismo , Ratos Sprague-Dawley , Fator de Crescimento Transformador beta1 , Genética , Metabolismo
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