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2.
Mem. Inst. Oswaldo Cruz ; 87(supl.5): 145-9, 1992.
Artigo em Inglês | LILACS | ID: lil-128436

RESUMO

Mechanisms of immune protection against the asexual blood stage infection by Plasmodium falciparum are reviewed. Recent studies of two independent lines of research developed at the Institute Pasteur, in humans and primate infections clearly indicate an obligatory interaction of antibodies and effector cells to express the anti-parasitic effect


Assuntos
Imunidade , Imunoglobulina G , Malária/imunologia
3.
Mem. Inst. Oswaldo Cruz ; 87(supl.3): 91-4, 1992. tab, ilus
Artigo em Inglês | LILACS | ID: lil-121081

RESUMO

We identified a gametocyte-specific protein of Plasmodium falciparum called Pf11-1 and provide experimental evidence that this molecule is involved in the emergence of gametes of the infected erythrocyte (gametogenesis). A mutant parasite clone, which has deleted over 90% of the PF11-1 gene locus, was an important control to establish the gametocyte-specific expression of the Pf11-1. Molecular analysis of the Pf11-1 deletion indicates that it is presumably due a chromosome breakage with subsequent "healing" by the addition of telomeric heptanucleotides. Moreover, similar DNA rearrangements are observed in most of the laboratory isolates during asexual propagation in vitro


Assuntos
Deleção Cromossômica , Antígenos de Histocompatibilidade , Plasmodium falciparum/ultraestrutura
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