Soluble vascular cell adhesion molecule - 1 [s. VCAM - 1] A marker of vascular dysfunction and progressive vascular diseases in diabetic patients

Advanced glycation endproducts [AGEs] which accumulate in diabetic vasculature results in enhanced expression of endothelial cell associated vascular cell adhesion molecule-1 [VCAM-1] as well as release of soluble form of VCAM-1 [s.VCAM-1] into culture supernatant. The present work was designed to study plasma s.VCAM-1 concentration in diabetic patients and its relation to microalbuminuria, to study the hypothesis that s.VCAM-1 in diabetic plasma might reflect early vascular perturbation in diabetic vasculopathy. Diabetic patients with microalbuminuria [patients at risk for vascular complication] had increased s.VCAM-1 when compared to diabetic patients without microalbuminuria [p < 0.05] and when compared to control [p < 0.05]. In conclusion, s.VCAM-1 can serve as a marker of ongoing vascular perturbation in diabetic patients and it may be of potential benefit in the assessment of success of therapeutic intervention intended to minimize vascular injury

Leucoctye acid phosphatase in haematologic disroders

Variations in the level of scores and reaction patterns of the acid phosphatase [APh] activity were estimated in blood films of 60 patients with various hematologic disorders and 30 normal controls using the azo-dye method of Goldberg and Barka [1962] with some modifications. The percentage of lymphocytes showing dot-like APh. Positivity was high in disseminated lymphoblastic lymphoma [T cell pattern], but low in acute and chronic lymphatic leukaemia [Non T pattern]. These findings are considered an additional proof to the validity of APh. As a cytochemical marker for the recognition of T-lymphocytes in malignant lymphoproliferative disorders. Also, our study showed that APh. May be helpful in the detection of remission in malignant lymphoma. Neutrophil APh. Activity is increased in malignant lympho-proliferative disorders, myeloproliferative disease, bacterial infection and leukaemoid reaction