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Southeast Asian J Trop Med Public Health ; 2005 Nov; 36(6): 1538-42
Artigo em Inglês | IMSEAR | ID: sea-33151

RESUMO

The strategy for screening of thalassemia and Hb E by a combination of osmotic fragility (OF) test and dichlorophenol indophenol precipitation (DCIP) test was validated with 436 unrelated Thai subjects. Hemoglobin (Hb) typing, Hb A2 quantitation, PCR and DNA sequence analysis were used as confirmatory methods for diagnosis of thalassemia and hemoglobinopathy. The sensitivity and specificity of this strategy was 100% and 79.7%, respectively. The results assessed by two medical scientists were exactly the same with 93.3% accuracy in comparison with the confirmatory methods. A combination of OF and DCIP has been shown to be a reliable, rapid, simple and sensitive strategy for screening thalassemia and Hb E in the Thai population.


Assuntos
2,6-Dicloroindofenol/diagnóstico , Testes Genéticos/métodos , Testes Hematológicos , Hemoglobina E/análise , Hemoglobinopatias/sangue , Heterozigoto , Humanos , Programas de Rastreamento/métodos , Reação em Cadeia da Polimerase , Valor Preditivo dos Testes , Análise de Sequência de DNA , Talassemia/sangue
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