Effect of chloroquine on liver weight of developing albino rats

To see the effect of chloroquine on liver weight of developing albino rats. Twenty four pregnant female albino rats were used and divided in 4 groups. They were kept in Animal House of Post Graduate Medical Institute, Lahore. Total gestational period in rats ranges from 20-22 days, which in this study was divided into three trimesters, each of seven days. Using oral dose of chloroquine 700mg/kg body weight in first second and third weeks of pregnancy. Chloroquine caused decrease in liver weight in offsprings specially in those which were exposed to drug during second and third week of pregnancy. The use of chloroquine should be avoided during pregnancy

Cutaneous atrophy following topical application of betamethasone on guinea pig skin

Corticosteroid induced histological changes were studied in the skin of guinea pig. Betamethasone-17-val crate [0.1%] ointment was applied twice daily to a small area of the animal's dorsal skin. Skin samples were excised from the treated areas every week for four weeks. Histological study was carried out under light microscope. The study revealed mild atrophic changes in the skin after the 4th week

Histological skin changes with clobetasol topical application

Topical corticosteroid, clobetasol-17-propionate [0.05%] was applied to the skin of guinea pigs. Skin samples were excised from the treated areas on weekly basis, for four weeks. Histological changes were noted under the light microscope. Epidermal atrophy was revealed after three weeks and moderate epidermal atrophy after four weeks