RESUMO
OBJECTIVE@#To evaluate the antibacterial and antifungal effects of cadmium(II) complexes with hexamethyltetraazacyclotetradecadiene ligands.@*METHODS@#Five coordinated square pyramidal cadmium(II) complexes and six coordinated square octahedral cadmium(II) complexes have been synthesized by interaction of 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene (denoted by L.2HClO4) and C-chiral isomers of its saturated analogue (denoted by 'teta' and 'tetb') with different salts of Cd(2+) ion [e.g. CdI2, Cd(NO3)2·6H2O, CdCl2·2H2O and Cd(ClO4)2·6H2O] in methanolic solution. Complexes of the ligands were investigated for antibacterial activity by disc diffusion method and antifungal effect by poisoned food technique.@*RESULTS@#The newly synthesized cadmium(II) complexes of the ligands were screened as potential antimicrobial agent against a number of medically important bacteria (Staphylococcus aureus, Bacillus cereus, Salmonella typhi, Shigella dysenteriae and Escherichia coli) and against two fungi (Candida albicans and Aspergillus aculeatus). The growth inhibiting activity of the ligands and complexes against bacteria and fungi were compared with the standard antibiotic ampicillin and commercially important antifungal agent, griseofulvin respectively. Among them some of the macrocyclic complexes were found to be more fungitoxic and antibacterial than the reference antifungal drug griseofulvin and antibacterial drug ampicillin respectively.@*CONCLUSIONS@#Hexamethyltetraazacyclotetradecadiene ligands and its complexes could be considered as very potential antibacterial and antifungal agent with further investigation.
RESUMO
Objective: To evaluate the antibacterial and antifungal effects of cadmium(II) complexes with hexamethyltetraazacyclotetradecadiene ligands. Methods: Five coordinated square pyramidal cadmium(II) complexes and six coordinated square octahedral cadmium(II) complexes have been synthesized by interaction of 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene (denoted by L.2HClO
RESUMO
The analgesic and anti-inflammatory activities of a new alkaloid, 1,2,3,9-tetrahydro-pyrrolo [2,1-b] quinazolin - 3-ylamine [compound 1] isolated from Sida cordifolia Linn. were investigated in animal models. In the acetic acid induced writhing model, the compound 1 showed 25.4 [p<0.05] and 52.43% [p<0.01] inhibition of writhing response at doses of 25 and 50 mg/kg body weight respectively. The alkaloid also produced significant increase in the tail flick latency in radiant heat tail-flick method. In Carrageenan induced rat paw edema the compound 1 produced 16.93 and 24.43% inhibition of paw edema at the doses of 25 and 50 mg/kg body weight respectively at the third hour of study