RESUMO
Background and Objective: Tapak Liman leaves have been long used traditionally for anemia. The dried powder form ofElephantropus scaber was extracted to produce ethanol. This study aimed to prove the hematopoietic effect of tapak limanleaf. Materials and Methods: The study was conducted for 28 days. The samples consisted of one non-anemic group andfour anemic groups induced by 130 mg/kgBW chloramphenicol given every day for 14 days. In the last day, group 2, 3 and 4were given the extract of tapak liman leaves for 10, 30 and 100 mg/kgBW; respectively. Group 5 (as a positive control) wasgiven physiological NaCl 0.9%. The testing doses were given once a day for 14 days, and the effects were observed on day1st , 14th, 21st, and 28th. Results: The parameters used in this study were erythrocyte, hemoglobin, reticulocyte andhematocrit counts in white mice that were analyzed by two-way ANOVA showing a significant value of (p<0.05).Conclusions: The extract of tapak liman leaves could increase hematopoietic activities; hence, it could be used as analternative therapy for anemia.
RESUMO
Objective: To assess cadmium sulfate (CdSO4) and zinc chloride (ZnCl2) antagonist effects on the prostate specific antigen and prostatic cell organization in rats. Methods: The study included 40 adult male rats, divided into four groups: Group 1 (CdSO4), Group 2 (ZnCl2), Group 3 (CdSO4-ZnCl2) and Group 4 (control). Animals were treated with CdSO4 and ZnCl2 at the same dose (15 mg/L) during 30 days. Results: It was showed a higher body weight and a lowering serum-prostate specific antigen concentration [(1.8 ± 0.6) ng/mL] in animals treated with CdSO4. CdSO4 induced a cyto-nuclear atypia, proliferative lesions, hyperplasia and precancerous foci in prostate tissue. Toxic effects of ZnCl2 were not recorded in this study. Conclusions: Protective role of zinc was exhibited against toxic effects of cadmium in prostate gland.