Hibernoma: A missed diagnosis!!

Hibernoma is a rare, benign soft tissue tumor described in <200 case reports/case series. It is slow-growing, painless, and commonly mistaken for lipoma or liposarcoma. Histopathological diagnosis is must for confirmation. Total excision is the treatment of choice. We present a rare case of hibernoma of thigh, which was initially misdiagnosed as atypical lipomatous tumor/well-differentiated liposarcoma on imaging, which turned out to be a hibernoma on histopathological examination.

Morphological Study of the Coronoid Process of Mandible in North Indian Population

Introduction: Morphological variations in coronoid process are produced by the corresponding developmental variations. The present study was conducted to assess morphological variations of coronoid process of mandible. Subjects and Methods: The present study was conducted in the department of Anatomy. It comprised of 100 subjects of both genders. All subjects were subjected to panoramic radiograph. The different shapes of coronoid process were compared. Results: Out of 100 subjects males were 50 and females were 50. Triangular shape coronoid process was seen in 32 males and 36 females, hook shaped in 14 males and 8 females and rounded shaped in 4 males and 6 females. The difference was non- significant (P> 0.05). On left side triangular shape was seen in 33 and 35 on right side, hook form was seen in 10 in left side and 7 in right side and rounded was seen 7 in left side and 8 in right side. The difference was non-significant (P> 0.05). Conclusion: Authors found variation in shape of coronoid process. Most common type was triangular followed by hook variety.

A 37-year-old male with extensive cerebral venous thrombosis: Clinicopathological correlation of a rare case

We present the autopsy findings and differential diagnosis of a 37-year-old immunocompetent male patient who presented primarily with extensive cerebral vein thrombosis and was found to have a rare association with JAK2V617F mutation positivity.

Recurrent nephrogenic adenoma of urinary bladder in a renal allograft recipient--a case report.

Nephrogenic adenoma is a rare benign tumour-like lesion within the urothelial mucosa of the urinary tract. It may be an incidental finding in bladder of a patient presenting with haematuria, dysuria and bladder growth after renal allograft transplant. Clinically it mimics bladder neoplasm. Definite diagnosis is established by histological examination of tumor. Though it attains an extensive spread in bladder mucosa and has a high tendency to recur, the clinical course is benign.

A study on sludge minimization during the treatment of pickling effluent.

In pickling industries, a lot of sludge is generated during the treatment of pickling effluent and there is severe problem of its disposal. Disposal of this sludge as per the Hazardous Waste (Management & Handling) Rules, 1989 is not easy. Its transportation and construction of lined disposal sites pose very severe problems. In the normal practice, the sludge is being disposed of at the sides of roads and railway tracks to fill low lying areas. This may cause serious health hazards. Considering these problems, a study has been undertaken to minimize the sludge generation during the treatment of pickling effluent by neutralizing it with lime, sodium hydroxide and combination of both. An attempt has been made to do an economic evaluation of the above process.

14C-urea breath test for assessment of gastric Helicobacter pylori colonization and eradication.

BACKGROUND AND OBJECTIVE: Urea breath test (UBT) is a reliable noninvasive technique for detecting gastric Helicobacter pylori colonization. 14C isotope-based test requires simple equipment and is inexpensive. We studied the utility of 14C-UBT in diagnosis of gastric H. pylori infection. METHODS: Presence of H. pylori was studied using antral histology and culture in patients with rapid urease test (RUT)-positive peptic ulcer. 14C-UBT was performed using a 185-kBq dose. Radioactivity in 15-min breath samples was measured using a beta-scintillation counter and result expressed as % dose recovered/mmol CO2. H. pylori was considered positive when any two tests were positive. All tests were repeated one month after completion of H. pylori eradication therapy. RESULTS: Among 41 patients (duodenal ulcer 36, gastric ulcer 5), H. pylori was detected by histology in 23 (56%) and by culture in 27 (66%). Overall, H. pylori was detected in 28 (68%) patients. Follow-up assessment was possible in 28 patients: 26 cleared the infection (all three tests negative). Mean 14C recovery values at 15 minutes associated with H. pylori-positive status were significantly higher (12.3 [SD 6.8] x 10(-3); n=30; p<0.001) than those associated with H. pylori-negative status (2.1 [0.9] x 10(-3); n=26). Using receiver-operating-characteristic analysis of 15-minute 14C recovery values, a cut-off of 6.5x10(-3) gave the best separation of H. pylori-positive and -negative cases. 14C-UBT had 93% sensitivity, 96% specificity and 95% accuracy. CONCLUSION: 14C-UBT appears to be a reliable noninvasive test for diagnosis of H. pylori infection.

Delay in presentation of oral cancer: a multifactor analytical study.

BACKGROUND: Patients with oral cancer often present late to the doctor making treatment difficult, expensive and sometimes unsuccessful. Delay in presentation may be considered to be a health risk-taking behaviour. The present study analyses the psychosocial factors related to delay in presentation of oral cancer patients through the Triandis' model of health-seeking behaviour and also examines the relationship between delay and the stage of cancer. METHODS: Seventy-nine oral cancer patients were interviewed after evolving a valid and reliable questionnaire, and determining the sample size. Univariate and multivariate logistic regression analysis was applied between demographic variables, psychosocial factors, primary delay (defined as delay between the first symptom and the seeking of medical advice), secondary delay (interval between the first consultation and presentation at the medical college), tertiary delay (delay in definitive treatment even after being seen at a tertiary care centre) and stage of the disease. Multiple logistic regression was also carried out. RESULTS: Primary delay ranged from less than a week in 5 (6.3%) patients to more than 1 year in 8 (10%) patients. A linear relationship was found between primary and secondary delay (F-statistic p < 0.0152). A majority of patients (70.9%) had advanced oral cancer. The stage of cancer at presentation to the hospital was significantly related to primary (G-test 6.3; p < 0.0121) but not to secondary delay. Multivariate analysis revealed that five variables, 'ill fated to have cancer', 'cancer a curse', 'non-availability of transport', 'trivial ulcers in mouth are self-limiting' and 'prolonged treatment renders family stressful' were significant independent predictors of primary delay. CONCLUSION: The identified independent predictors of primary delay should be used to develop the main theme of an educational intervention programme for patients with oral cancer.

Comparative evaluation of serological tests for diagnosis of visceral leishmaniasis.

Sensitivity and specificity of the direct agglutination (DAT) and indirect immunofluorescent test (IFT) have been compared with indirect immunoperoxidase assay (IPA) for the serodiagnosis of visceral leishmaniasis. IPA and DAT were found to be more sensitive and specific than IFT. Indirect immunoperoxidase test was found to be better than DAT as preparation of antigen is easy. Less amount of antigen is required, storage of antigen in slide form is more convenient and shelf life is longer. It is easier to read and interpret immunoperoxidase with the help of ordinary light microscope and chances of false positive and false negatives are negligible.