RESUMO
We report a case of a young Kuwaiti gentleman who presented with severe diabetic ketoacidosis [DKA] associated with atypical antipsychotic drug olanzapine. The current medical literature suggest that atypical antipsychotic drugs, including olanzapine lead to weight gain, insulin resistance, impaired glucose tolerance [IGT], diabetes mellitus [DM] and rarely patient may presents with serious side effects like DKA. Clinicians are urged to monitor the emergence of metabolic risk factors periodically and remain aware of potentially serious effects like DKA in schizophrenic patients taking olanzapine
Assuntos
Humanos , Masculino , Antipsicóticos/efeitos adversos , Complicações do Diabetes , Inibidores Seletivos de Recaptação de Serotonina/efeitos adversos , Benzodiazepinas/efeitos adversosRESUMO
We report a young Kuwaiti gentleman who presented with severe diabetic ketoacidosis [DKA] associated with atypical antipsychotic drug olanzapine. The current medical literature suggests that atypical antipsychotic drugs, including olanzapine lead to weight gain, insulin resistance, impaired glucose tolerance, diabetes mellitus [DM] and rarely patient may present with serious side effects like DKA. Clinicians are urged to monitor the emergence of metabolic risk factors periodically and remain aware of potentially serious effects like DKA in schizophrenic patients taking olanzapine
RESUMO
PURPOSE: To study the role of vitamin E in preventing cataract formation in experimental animals. METHODS: An experimental model (selenite cataract) was selected for this study. Selenite cataract was produced in rats by subcutaneous administration of sodium selenite. Biochemical and histological changes following induction of selenite cataract in weanling Wistar rats were studied vis-a-vis the role of vitamin E in attenuating or preventing cataractogenesis. RESULTS: Vitamin E was capable of preventing selenite cataractogenesis. Selenite cataract did not develop in 91.6% (11 of 12) and 76.7% (8 of 12) vitamin E treated rats, when administered on the 12th and 10th post partum day respectively. CONCLUSION: The study confirmed that selenite induced cataract in Wistar rats is attenuated by vitamin E.