Antihypertensive effect of manidipine hydrochloride (Madiplot) in Hanoi Huu Nghi Hospital (2001-2002)

49 male patients between 45 and 70 years of age with hypertension and type 2 diabetes were studied to evaluate the effect of manidipine hydrochloride (Madiplot produced by Takeda - Japan) and side effects of this medication. Patients were taken 10-20 mg manidipine/day during 6 months. The result showed that manidipine reduced systolic blood pressure, diastolic blood pressure, and average blood pressure significantly but did not change heart rate during treatment period. Side effects were not much and this medication can be used to treat hypertension for long time

Assessment the effects of kidney protection of Enalapril in patients with kidney failure at I, II stages follow by hypertensive type 2 diabetes

Study on 50 male patients with hypertension of I-II degrees; kidney failure at I, II stages and type 2 diabetes according to the criteria of WHO. Results: Enalapril is a drug of angiotensine-converting enzyme inhibitors which had effect of decrease of systolic, diastolic and mean blood pressure. This drug slow down a process of chronic kidney failure at stage I-II (there were no changes in level of filting kidney, blood creatinine, decrease of ureteral protein); the unexpected effects were small so that drug seems to safe and well tolerated.