Prevalence and Pattern of Soil Transmitted Helminths (Sths) among Primary School Children at Nnewi, Nnewi- North Local Government Area, Anambra State, Nigeria

Soil Transmitted Helminths (STHs) are of great Public Health importance. The present study was designed to evaluate the prevalence and pattern of STHs among Primary School Children at Nnewi, Nnewi North Local Government Area of Anambra State, Nigeria. 250 school children aged 1-12 years were randomly recruited from 5 major primary schools at Nnewi between January and June 2017. 95 (38%) were males while 155 (62%) were females. Stool samples were collected using universal sterile containers and examined microscopically using saline floatation method. Out of the 250 pupils examined, 105 (42%) were positive for at least one STH. 40 (42.1%) of the males examined were positive while 65 (41.9%) of the females were positive. There was no significant difference between sexes (P > 0.05). Children aged 1-5 years had the highest prevalence (62.2%), followed by those aged 6-8 years (33.3). Children aged 9-12 years had the least prevalence. Prevalence was significantly different between the different age groups (P < 0.05). Among the STHs isolated, Ascaris lumbricoides was the most prevalent (22%), followed by Hookworm (14%). The least prevalent was Trichuris trichiura (6%). No case of mixed infection was detected. The study concludes that STHs are of immense public Health importance in primary School children at Nnewi and efforts should be intensified to promote health education, personal hygiene and sanitation and regular deworming of school children.

Epidemiology and Pattern of Osteoarthritis at Ogbaku, Imo State University Teaching Hospital Annex, Mbaitoli Local Government Area, Imo State, Southeast, Nigeria.

Background: Osteoarthritis is a major cause of disability and incapacitation Worldwide. Aim: To evaluate the epidemiology and pattern of osteoarthritis at Ogbaku, Imo State University Teaching Hospital annex, Mbaitoli Local Government Area, Imo State, South-east Nigeria. Study Design: A retrospective epidemiological study. Methodology: One hundred and six case notes of patients managed for osteoarthritis between January 2009 and October 2010 were studied. Simple statistical methods like percentages were used for data analysis. Results: Out of 106 cases studied, 72(67.9%) were females while 43(32.1%) were males. The highest percentage of cases (34%) occurred in people aged 65-74 years followed by people aged 55-64 years (24.5%). Younger people (45-54 years) were the least affected. Farmers (24.5%) were the most affected occupational group followed by athletes (18.9%) and then traders (17%). Civil servants were the least affected. The knee (41.5%) was the most frequently affected joint followed by the hip (22.6%). The least affected joints were the wrist (1.9%) and the elbow (1.9%). Conclusion: The study shows that osteoarthritis occurred most in people aged 65-74 yrs and the knee was the most frequently affected joint in the body.

Possible biochemical impact of malaria infection in subjects with HIV co-infection in Anambra state, Nigeria.

BACKGROUND & OBJECTIVES: The present study was designed to determine possible contributory impact of malaria infection on some biochemical markers in subjects with HIV co-infection in order to know if they are adverse or protective. METHODS: Participants were recruited at the Voluntary Counseling and Testing Unit, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria and grouped into: (i) Malaria and HIV co-infection group (n = 45); and (ii) HIV infected group without concurrent malaria infection (n = 57). Standard laboratory methods were used for the HIV and Plasmodium falciparum antigen screening, malaria parasite density, CD4+ T-cell count, packed cell volume, white blood cell count, serum iron and albumin concentrations. RESULTS: The results showed that serum iron and albumin were significantly reduced and raised respectively in 'Malaria-HIV co-infection group' compared with 'HIV infection group' (p < 0.05 and p < 0.05). A positive association was observed between age and serum iron concentration in malaria and HIV co-infected group (r = 0.580; p < 0.05) while negative associations were observed between PCV and serum iron (r = - 0.388; p < 0.05) and between CD4+ T-cells and serum iron concentration (r = -0.362; p < 0.05) in malaria and HIV co-infected group. The CD4+ T-cell count, WBC count, PCV were not significantly different between the Malaria-HIV co-infection group and HIV infection group. INTERPRETATION & CONCLUSION: In the present study serum iron and albumin concentrations were the most sensitive indicators that showed the contributory impact of malaria infection on biochemical index in HIV co-infected subjects. The findings suggest that at the defined stage of HIV infection in the present study, malaria co-infection may moderate the impact of HIV infection on iron metabolism and hepatic synthesis of albumin.

Prevalence of malaria as co-infection in HIV-infected individuals in a malaria endemic area of southeastern Nigeria.

BACKGROUND & OBJECTIVE: The present study was conducted on the prevalence of malaria as co-infection amongst 'asymptomatic HIV' and 'symptomatic HIV' subjects to see if such prevalence deviated from that commonly reported in apparently health individuals in same locality. METHODS: A prospective study that involved 196 participants grouped according to their HIV status as: 'asymptomatic HIV seropositive group' (n = 101); 'symptomatic HIV seropositive group' (n = 48) and 'control HIV-seronegative group (n = 47). Blood samples collected from the participants were used for double HIV screening by rapid immunoassay technique and immunochromatographic technique, and for the diagnosis of Plasmodium falciparum malaria using rapid P. falciparum antigen detection method. RESULTS: The result showed that the prevalence of P. falciparum malaria as a co-infection amongst the asymptomatic HIV seropositive group was 12 (11.8%) and amongst the symptomatic HIV seropositive group was 16 (33.3%). However, the prevalence rate of P. falciparum malaria amongst the control HIV seronegative group was 5 (10.6%) and the combined burden of P. falciparum malaria amongst both groups of HIV seropositives was 28 (18.9%). INTERPRETATION & CONCLUSION: The present study observed different prevalence rates of P. falciparum malaria amongst the three groups. The prevalence was tripled in symptomatic HIV seropositive group. This shows a clear departure from possible obtainable prevalence of malaria infection alone in this malaria endemic area. Due to the mortality rates associated with malaria infection in an endemic area, it may be necessary that routine malaria screening be adopted as part of the management policy to check the co-infection.