RESUMO
Infradian modulation with periods of 168 h and 120 h characterizes the RNA, DNA and lipid content of the liver in adult female Lewis/S rats. Multilinear analysis shwos that the fit of an infradian cosine curve with these periods is statistically significant below the 5% level (P = 0.011;P = 0.007 and P = 0.013) and that they account for 19.0, 22.7 and 20.1% of the overall variability, respectively
Assuntos
Ratos , Animais , Feminino , Ciclos de Atividade , DNA/metabolismo , Fígado/metabolismo , Lipídeos/metabolismo , RNA/metabolismo , Malária/imunologia , Plasmodium berghei/patogenicidade , Ratos Endogâmicos Lew , VirulênciaRESUMO
The objective of the study was to determine the circadian effects of melatonin and two different ACTH preparations: a synthetic heptadecapeptide with adrenocorticotrophic action (synchrodyn 1-17, HOE 433) and a natural ACTH (Acthar, Armour). Both ACTH preparations acted in a circadian stage-dependent fashion affecting the MESOR and the amplitude of total protein synthesis of rat adrenal cells. The results also indicated interaction of melatonin with the rhythmic action of ACTH. We conclude that circadian adrenocortical organization also modulates protein synthesis