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1.
J Biosci ; 2000 Sep; 25(3): 235-42
Artigo em Inglês | IMSEAR | ID: sea-110798

RESUMO

Expression of cytokeratins (CK), a subset of intermediate filament (IF) proteins in epithelia, is developmentally regulated. CK expression may also change after malignant transformation. Our earlier studies on CK expression in human oral tumours and pre-cancerous lesions have shown specific changes in CK expression. We analysed CK expression in human tongue and buccal mucosa (BM) in fetuses in the embryonic age group of 16 to 27 weeks using biochemical and immunohistochemical techniques to find out whether there is any similarity in CK expression in human oral squamous cell carcinomas (SCC) and fetal oral tissues. CK 1, 8 and 18 were detected in a majority of samples using both techniques. Our earlier studies had shown aberrant expression of CK 1 and 18 in many of the oral SCC and leukoplakias. Studies by immunohistochemistry showed that these different CK antigens were expressed in different cell layers. CK 1(2) were present in the stratified epithelial layers whereas CK 8 and 18 were restricted to glandular epithelium. Till 27 weeks of gestation, both tongue and BM expressed CK 1, 8 and 18 along with CK 6 and 16. Thus, fetal tissues showed some similarities in CK pattern with their respective SCC.


Assuntos
Eletroforese em Gel Bidimensional , Proteínas Fetais/biossíntese , Técnica Indireta de Fluorescência para Anticorpo , Regulação da Expressão Gênica no Desenvolvimento , Idade Gestacional , Humanos , Queratinas/biossíntese , Isoformas de Proteínas/biossíntese
2.
J Postgrad Med ; 1993 Jan-Mar; 39(1): 40-1
Artigo em Inglês | IMSEAR | ID: sea-115230

RESUMO

An 11 year old boy presenting with cystic lump in left hypochondrium was diagnosed to have splenic cyst and treated successfully by splenectomy. Large, infected cyst involving hilum was the indication.


Assuntos
Criança , Cistos/diagnóstico , Humanos , Masculino , Esplenopatias/diagnóstico
3.
J Postgrad Med ; 1992 Jan-Mar; 38(1): 37-40, 40A-40B
Artigo em Inglês | IMSEAR | ID: sea-115588

RESUMO

Characteristically continuous facial myokymia is a pathognomonic, exceedingly rare physical sign of intrinsic brain-stem lesions e.g. multiple sclerosis (where the myokymia lasts only for a few months), pontine glioma (where it is unremitting for years). The physiopathogenesis is unclear. Electromyographic patterns are characteristic. Therapy and prognosis are related to the basic aetio-pathological process. Only two out of 132 cases of intrinsic brain-stem lesions in the department of Neurosurgery, Seth G.s. Medical College, Bombay over a period of 3 decades, exemplify its rarity. These two cases are reported here and the relevant literature is reviewed.


Assuntos
Adulto , Neoplasias Encefálicas/fisiopatologia , Tronco Encefálico/fisiopatologia , Irradiação Craniana , Eletromiografia , Potenciais Evocados Auditivos do Tronco Encefálico/fisiologia , Músculos Faciais/inervação , Fasciculação/fisiopatologia , Feminino , Glioma/fisiopatologia , Humanos , Masculino , Tomografia Computadorizada por Raios X
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